Central sensitization in chronic low back pain: A narrative review

Ilaria Sanzarello, Luciano Merlini, Michele Attilio Rosa, Mariada Perrone, J. Frugiuele, Raffaele Borghi, Cesare Faldini

Research output: Contribution to journalReview articlepeer-review


Low back pain is one of the four most common disorders in all regions, and the greatest contributor to disability worldwide, adding 10.7% of total years lost due to this health state. The etiology of chronic low back pain is, in most of the cases (up to 85%), unknown or nonspecific, while the specific causes (specific spinal pathology and neuropathic/radicular disorders) are uncommon. Central sensitization has been recently recognized as a potential pathophysiological mechanism underlying a group of chronic pain conditions, and may be a contributory factor for a sub-group of patients with chronic low back pain. The purposes of this narrative review are twofold. First, to describe central sensitization and its symptoms and signs in patients with chronic pain disorders in order to allow its recognition in patients with nonspecific low back pain. Second, to provide general treatment principles of chronic low back pain with particular emphasis on pharmacotherapy targeting central sensitization.
Original languageEnglish
Pages (from-to)625-633
Number of pages9
JournalJournal of Back and Musculoskeletal Rehabilitation
Issue number4
Publication statusPublished - Nov 29 2016


  • Chronic low back pain
  • chronic disorders
  • central sensitization


Dive into the research topics of 'Central sensitization in chronic low back pain: A narrative review'. Together they form a unique fingerprint.

Cite this