Central sleep apnea in left ventricular dysfunction: Prevalence and implications for arrhythmic risk

Paola A. Lanfranchi, Virend K. Somers, Alberto Braghiroli, Ugo Corra, Ermanno Eleuteri, Pantaleo Giannuzzi

Research output: Contribution to journalArticle

Abstract

Background - The prevalence and characteristics of sleep-disordered breathing in patients with asymptomatic left ventricular (LV) dysfunction are unknown. Therefore, we evaluated the prevalence of sleep-disordered breathing in patients with LV dysfunction without overt heart failure and tested the hypothesis that sleep-disordered breathing is linked to greater hemodynamic and autonomic impairment. Methods and Results - We studied 47 patients with LV ejection fractions ≤40% without any history of heart failure. Central sleep apnea (CSA), as defined by an apnea-hypopnea index ≥15/h, was present in 26 patients (55%), 17 (36%) of whom had severe CSA (apnea-hypopnea index ≥30/h). Obstructive sleep apnea was evident in 5 patients (11%). The prevalence and severity of CSA were higher in patients with ischemic cardiomyopathy than in patients with nonischemic cardiomyopathy (P

Original languageEnglish
Pages (from-to)727-732
Number of pages6
JournalCirculation
Volume107
Issue number5
DOIs
Publication statusPublished - Feb 11 2003

Keywords

  • Heart failure
  • Nervous system, autonomic
  • Sleep
  • Tachyarrhythmias

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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