Central toxic effects of chronic ethanol treatment: Actions on GABA and benzodiazepine recognition sites

A. Bosio, L. Lucchi, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticle

Abstract

Prolonged ethanol treatment modifies various neurotransmitter systems. GABAergic neuronal function was particularly affected. On the other hand, clinical reports have indicated an interaction between ethyl alcohol and benzodiazepine receptors. These observations suggest a possible site of action of ethanol at the level of the GABA-benzodiazepine receptor complex. Our results showed that ethanol treatment differentially affected GABA receptor function and benzodiazepine binding sites. When [3H]GABA binding in the cerebellum, striatum and hippocampus was increased, [3H]diazepam binding remained unchanged in the same areas. The possibility of modulation of ethanol effects on GABAergic neurons through benzodiazepine receptors is discussed.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalToxicology Letters
Volume13
Issue number1-2
DOIs
Publication statusPublished - 1982

    Fingerprint

ASJC Scopus subject areas

  • Toxicology
  • Medicine(all)

Cite this