Central vagotonic effects of atropine modulate spectral oscillations of sympathetic nerve activity

Nicola Montano, Chiara Cogliati, Alberto Porta, Massimo Pagani, Alberto Malliani, Krzysztof Narkiewicz, Francois M. Abboud, Clay Birkett, Virend K. Somers

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Low-dose atropine causes bradycardia either by acting on the sinoatrial node or by its effects on central muscarinic receptors increasing vagal activity. Any central muscarinic effects of high-dose atropine on RR interval are masked by peripheral muscarinic blockade at the sinoatrial node, which causes tachycardia. Effects of central parasympathetic activation on sympathetic activity are not known. Methods and Results - Using power spectral analysis of RR interval, intra-arterial blood pressure, respiration, and muscle sympathetic nerve activity (MSNA), we examined the effects of both low (2 μg/kg IV) and high (15 μg/kg IV) doses of atropine. After low-dose atropine, RR increased by 9±1% (P

Original languageEnglish
Pages (from-to)1394-1399
Number of pages6
JournalCirculation
Volume98
Issue number14
Publication statusPublished - Oct 6 1998

Keywords

  • Heart rate
  • Muscles
  • Nervous system, autonomic
  • Nervous system, sympathetic
  • Vagus nerve

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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