Central vagotonic effects of atropine modulate spectral oscillations of sympathetic nerve activity

Nicola Montano, Chiara Cogliati, Alberto Porta, Massimo Pagani, Alberto Malliani, Krzysztof Narkiewicz, Francois M. Abboud, Clay Birkett, Virend K. Somers

Research output: Contribution to journalArticle

Abstract

Background - Low-dose atropine causes bradycardia either by acting on the sinoatrial node or by its effects on central muscarinic receptors increasing vagal activity. Any central muscarinic effects of high-dose atropine on RR interval are masked by peripheral muscarinic blockade at the sinoatrial node, which causes tachycardia. Effects of central parasympathetic activation on sympathetic activity are not known. Methods and Results - Using power spectral analysis of RR interval, intra-arterial blood pressure, respiration, and muscle sympathetic nerve activity (MSNA), we examined the effects of both low (2 μg/kg IV) and high (15 μg/kg IV) doses of atropine. After low-dose atropine, RR increased by 9±1% (P

Original languageEnglish
Pages (from-to)1394-1399
Number of pages6
JournalCirculation
Volume98
Issue number14
Publication statusPublished - Oct 6 1998

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Atropine
Sinoatrial Node
Cholinergic Agents
Muscarinic Receptors
Bradycardia
Tachycardia
Arterial Pressure
Respiration
Muscles

Keywords

  • Heart rate
  • Muscles
  • Nervous system, autonomic
  • Nervous system, sympathetic
  • Vagus nerve

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Montano, N., Cogliati, C., Porta, A., Pagani, M., Malliani, A., Narkiewicz, K., ... Somers, V. K. (1998). Central vagotonic effects of atropine modulate spectral oscillations of sympathetic nerve activity. Circulation, 98(14), 1394-1399.

Central vagotonic effects of atropine modulate spectral oscillations of sympathetic nerve activity. / Montano, Nicola; Cogliati, Chiara; Porta, Alberto; Pagani, Massimo; Malliani, Alberto; Narkiewicz, Krzysztof; Abboud, Francois M.; Birkett, Clay; Somers, Virend K.

In: Circulation, Vol. 98, No. 14, 06.10.1998, p. 1394-1399.

Research output: Contribution to journalArticle

Montano, N, Cogliati, C, Porta, A, Pagani, M, Malliani, A, Narkiewicz, K, Abboud, FM, Birkett, C & Somers, VK 1998, 'Central vagotonic effects of atropine modulate spectral oscillations of sympathetic nerve activity', Circulation, vol. 98, no. 14, pp. 1394-1399.
Montano N, Cogliati C, Porta A, Pagani M, Malliani A, Narkiewicz K et al. Central vagotonic effects of atropine modulate spectral oscillations of sympathetic nerve activity. Circulation. 1998 Oct 6;98(14):1394-1399.
Montano, Nicola ; Cogliati, Chiara ; Porta, Alberto ; Pagani, Massimo ; Malliani, Alberto ; Narkiewicz, Krzysztof ; Abboud, Francois M. ; Birkett, Clay ; Somers, Virend K. / Central vagotonic effects of atropine modulate spectral oscillations of sympathetic nerve activity. In: Circulation. 1998 ; Vol. 98, No. 14. pp. 1394-1399.
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AU - Narkiewicz, Krzysztof

AU - Abboud, Francois M.

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