Central venous access device (CVAD) complications in Haemophilia with inhibitors undergoing immune tolerance induction: Lessons from the international immune tolerance study

V. Rodriguez, M. E. Mancuso, D. Warad, C. R M Hay, D. M. Dimichele, L. Valentino, G. Kenet, R. Kulkarni

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Central venous access devices (CVADs) are frequently required as stable long-lasting venous access in children with haemophilia, especially those requiring immune tolerance induction (ITI) for inhibitors. CVAD infection is one of the most frequently reported catheter-related complications in this patient population. Aim: Detailed review of CVAD complications from the International ITI (I-ITI) study and analysis of potential risk factors for such complications. Methods: Retrospective analysis of prospectively obtained data from the I-ITI study primarily focused on CVAD-related complications. Results: A total of 115 children were recruited and 183 CVADs were placed in 99 subjects resulting in 121,206 CVAD-days observed on-study. A total of 124 CVAD infections were reported in 41 of 99 (41%) subjects with an overall infection rate of 0.94 per 1000 CVAD-days (interquartile ranges 0-1.7). A similar number of infections were observed in the two treatment arms (median: 2 and 3 in high dose and low dose respectively). Infections occurred more frequently in the presence of external catheters than with fully implanted catheters (P = 0.026). Infected patients were significantly younger at the time of CVAD insertion (median age: 22 vs. 25 months, P = 0.020). Patients with Gram-positive infections were also significantly younger than those with Gram-negative infections (median age: 17 vs. 25 months, P <0.0001). Conclusion: CVAD infection was the most common complication observed in children with severe haemophilia and inhibitors in the frame of the I-ITI study. Younger age at CVAD insertion and external CVAD were associated with higher risk for infection. ITI outcome was unaffected by CVAD infections.

Original languageEnglish
Pages (from-to)e369-e374
JournalHaemophilia
Volume21
Issue number5
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • Central venous access
  • Complications
  • Immune tolerance
  • Inhibitors

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)

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