Central venous catheter-related complications in children with oncological/hematological diseases: An observational study of 418 devices

G. Fratino, A. C. Molinari, S. Parodi, S. Longo, P. Saracco, Elio Castagnola, R. Haupt

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The use of indwelling central venous catheters (CVCs) has become commonplace in the management of children undergoing anticancer treatment. Several types of CVC are available, while information on complications observed in children is scarce. We describe the experience of two tertiary care centers in Italy that prospectively followed up three types of CVC used at both institutions over a 30-month period. Patients and methods: Between January 2000 and May 2002, double-lumen (DL) or single-lumen (SL) Hickman-Broviac (HB) catheters, and single-lumen pressure-activated safety valve (PASV) catheters were used and prospectively evaluated. Four types of possible complication were defined a priori: mechanical, thrombotic, malfunctioning and infectious. Results: Four hundred and eighteen CVCs (180 SL-HB, 162 DL-HB and 76 PASV) were inserted in 368 children, for a total of 107 012 catheter days at risk of complication. At least one complication occurred while using 169 of the devices (40%): 46% of the DL-HB, 46% of the PASV and 33% of the SL-HB (P = 0.02) catheters. Subjects with hematological malignancies or non-malignant diseases had significantly more complications than those with solid tumors (P

Original languageEnglish
Pages (from-to)648-654
Number of pages7
JournalAnnals of Oncology
Volume16
Issue number4
DOIs
Publication statusPublished - Apr 2005

Keywords

  • Central venous catheters
  • Infections
  • Surgical complications
  • Thrombosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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