Centrally mediated inhibition of local inflammation by ciliary neurotrophic factor

Cristina Meazza, Annalise Di Marco, Paolo Fruscella, Isabelle Gloaguen, Ralph Laufer, Marina Sironi, Jean D. Sipe, Pia Villa, Maria Romano, Pietro Ghezzi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Since ciliary neurotrophic factor (CNTF) inhibits the production of TNF and activates the hypothalamus-pituitary-adrenal axis (HPAA), we investigated whether CNTF can produce antiinflammatory actions and whether it may act through a central mechanism, using the murine air pouch model of inflammation. In this model, inflammation is evaluated by measuring the induction of TNF and IL-6 as well as cell recruitment in the pouch fluid 24 h after carrageenan. Intracerebroventricular injection, but not intravenous or local injection of CNTF markedly inhibited inflammation. This was associated with high serum corticosterone levels, and antiinflammatory action was not observed in adrenalectomized mice, indicating that an intact HPAA is required. A CNTF receptor antagonist increased carrageenan inflammation, suggesting that endogenous CNTF might have a centrally mediated antiinflammatory role.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalNeuroImmunoModulation
Volume4
Issue number5-6
Publication statusPublished - May 1997

Fingerprint

Ciliary Neurotrophic Factor
Inflammation
Anti-Inflammatory Agents
Carrageenan
Hypothalamus
Ciliary Neurotrophic Factor Receptor
Corticosterone
Intravenous Injections
Interleukin-6
Air
Injections
Serum

Keywords

  • Ciliary neurotrophic factor
  • Corticosterone
  • Inflammation
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Immunology

Cite this

Meazza, C., Di Marco, A., Fruscella, P., Gloaguen, I., Laufer, R., Sironi, M., ... Ghezzi, P. (1997). Centrally mediated inhibition of local inflammation by ciliary neurotrophic factor. NeuroImmunoModulation, 4(5-6), 271-276.

Centrally mediated inhibition of local inflammation by ciliary neurotrophic factor. / Meazza, Cristina; Di Marco, Annalise; Fruscella, Paolo; Gloaguen, Isabelle; Laufer, Ralph; Sironi, Marina; Sipe, Jean D.; Villa, Pia; Romano, Maria; Ghezzi, Pietro.

In: NeuroImmunoModulation, Vol. 4, No. 5-6, 05.1997, p. 271-276.

Research output: Contribution to journalArticle

Meazza, C, Di Marco, A, Fruscella, P, Gloaguen, I, Laufer, R, Sironi, M, Sipe, JD, Villa, P, Romano, M & Ghezzi, P 1997, 'Centrally mediated inhibition of local inflammation by ciliary neurotrophic factor', NeuroImmunoModulation, vol. 4, no. 5-6, pp. 271-276.
Meazza C, Di Marco A, Fruscella P, Gloaguen I, Laufer R, Sironi M et al. Centrally mediated inhibition of local inflammation by ciliary neurotrophic factor. NeuroImmunoModulation. 1997 May;4(5-6):271-276.
Meazza, Cristina ; Di Marco, Annalise ; Fruscella, Paolo ; Gloaguen, Isabelle ; Laufer, Ralph ; Sironi, Marina ; Sipe, Jean D. ; Villa, Pia ; Romano, Maria ; Ghezzi, Pietro. / Centrally mediated inhibition of local inflammation by ciliary neurotrophic factor. In: NeuroImmunoModulation. 1997 ; Vol. 4, No. 5-6. pp. 271-276.
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