Centric fission of chromosome No. 4 in the mother of two patients with trisomy 4p

Bruno Dallapiccola, Pierpaolo Mastroiacovo, Enrico Gandini

Research output: Contribution to journalArticle

Abstract

Centric fission of chromosome No. 4 was found in the healthy mother of two children with trisomy 4p. The two telocentrics derived are stable and show no evidence of fusing again. the 2:3 ratio of unbalanced offsprings born to the proposita indicates that, contrary to the evidence emerging from studies in other species, the risk for the production of unbalanced gametes is high.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalHuman Genetics
Volume31
Issue number1
DOIs
Publication statusPublished - Jan 1976

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics
  • Medicine(all)

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