Centrocytic-like lymphoma associated with localized amyloidosis of the large intestine

R. Ranaldi, G. Goteri, A. Santinelli, B. Rezai, I. Bearzi, S. Pileri, S. Poggi

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A case of low-grade centrocytic-like (CCL) B-cell lymphoma involving the large intestine, the regional lymph nodes and the spleen is reported. In the large intestine the lymphomatous infiltrate was restricted to sites of intense antigenic stimulation (diverticula, appendix, ileo-caecal valve) and was associated with marked plasma cell differentiation and massive amyloid deposits. The immunophenotype was CD20, CD21, CD45RA/MB1/MT2, CD68, CD45 related/Ki-B3 and HLA-DR positive, and MB2, DBA.44 reactive regarding the CCL cell lymphoma subpopulation; and IgG-λ positive regarding its plasma cell fraction.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
JournalVirchows Archiv
Issue number3
Publication statusPublished - 2004


  • Centrocytic-like lymphoma
  • Large intestine
  • Localized amyloidosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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