TY - JOUR
T1 - Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization
AU - Sorino, Cristina
AU - Bruno, Tiziana
AU - Desantis, Agata
AU - Di Certo, Maria Grazia
AU - Iezzi, Simona
AU - De Nicola, Francesca
AU - Catena, Valeria
AU - Floridi, Aristide
AU - Chessa, Luciana
AU - Passananti, Claudio
AU - Cundari, Enrico
AU - Fanciulli, Maurizio
PY - 2013/8/9
Y1 - 2013/8/9
N2 - Background: Che-1 is an RNA polymerase II-binding protein involved in gene transcription, cell proliferation, and DNA damage response. Results: Che-1 localizes at interphase centrosomes. Che-1 inhibition abolishes Chk1 localization at centrosomes, advancing entry into mitosis. Conclusion: Che-1 acts like an upstream regulator of Chk1 centrosomal functions. Significance: Che-1 inhibition might potentiate tumor cell sensitivity to antimitotic drugs.
AB - Background: Che-1 is an RNA polymerase II-binding protein involved in gene transcription, cell proliferation, and DNA damage response. Results: Che-1 localizes at interphase centrosomes. Che-1 inhibition abolishes Chk1 localization at centrosomes, advancing entry into mitosis. Conclusion: Che-1 acts like an upstream regulator of Chk1 centrosomal functions. Significance: Che-1 inhibition might potentiate tumor cell sensitivity to antimitotic drugs.
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U2 - 10.1074/jbc.M113.465302
DO - 10.1074/jbc.M113.465302
M3 - Article
C2 - 23798705
AN - SCOPUS:84881397030
VL - 288
SP - 23348
EP - 23357
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 32
ER -