Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization

Cristina Sorino, Tiziana Bruno, Agata Desantis, Maria Grazia Di Certo, Simona Iezzi, Francesca De Nicola, Valeria Catena, Aristide Floridi, Luciana Chessa, Claudio Passananti, Enrico Cundari, Maurizio Fanciulli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Che-1 is an RNA polymerase II-binding protein involved in gene transcription, cell proliferation, and DNA damage response. Results: Che-1 localizes at interphase centrosomes. Che-1 inhibition abolishes Chk1 localization at centrosomes, advancing entry into mitosis. Conclusion: Che-1 acts like an upstream regulator of Chk1 centrosomal functions. Significance: Che-1 inhibition might potentiate tumor cell sensitivity to antimitotic drugs.

Original languageEnglish
Pages (from-to)23348-23357
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
Publication statusPublished - Aug 9 2013

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization'. Together they form a unique fingerprint.

Cite this