Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization

Cristina Sorino; Tiziana Bruno; Agata Desantis; Maria Grazia Di Certo; Simona Iezzi; Francesca De Nicola; Valeria Catena; Aristide Floridi; Luciana Chessa; Claudio Passananti; Enrico Cundari; Maurizio Fanciulli

doi:10.1074/jbc.M113.465302

Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization

Cristina Sorino, Tiziana Bruno, Agata Desantis, Maria Grazia Di Certo, Simona Iezzi, Francesca De Nicola, Valeria Catena, Aristide Floridi, Luciana Chessa, Claudio Passananti, Enrico Cundari, Maurizio Fanciulli

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Che-1 is an RNA polymerase II-binding protein involved in gene transcription, cell proliferation, and DNA damage response. Results: Che-1 localizes at interphase centrosomes. Che-1 inhibition abolishes Chk1 localization at centrosomes, advancing entry into mitosis. Conclusion: Che-1 acts like an upstream regulator of Chk1 centrosomal functions. Significance: Che-1 inhibition might potentiate tumor cell sensitivity to antimitotic drugs.

Original language	English
Pages (from-to)	23348-23357
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M113.465302
Publication status	Published - Aug 9 2013

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

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Sorino, C., Bruno, T., Desantis, A., Di Certo, M. G., Iezzi, S., De Nicola, F., Catena, V., Floridi, A., Chessa, L., Passananti, C., Cundari, E., & Fanciulli, M. (2013). Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization. Journal of Biological Chemistry, 288(32), 23348-23357. https://doi.org/10.1074/jbc.M113.465302

Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization. / Sorino, Cristina; Bruno, Tiziana; Desantis, Agata; Di Certo, Maria Grazia; Iezzi, Simona; De Nicola, Francesca; Catena, Valeria; Floridi, Aristide; Chessa, Luciana; Passananti, Claudio; Cundari, Enrico; Fanciulli, Maurizio.

In: Journal of Biological Chemistry, Vol. 288, No. 32, 09.08.2013, p. 23348-23357.

Research output: Contribution to journal › Article › peer-review

Sorino, C, Bruno, T, Desantis, A, Di Certo, MG, Iezzi, S, De Nicola, F, Catena, V, Floridi, A, Chessa, L, Passananti, C, Cundari, E & Fanciulli, M 2013, 'Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization', Journal of Biological Chemistry, vol. 288, no. 32, pp. 23348-23357. https://doi.org/10.1074/jbc.M113.465302

Sorino, Cristina ; Bruno, Tiziana ; Desantis, Agata ; Di Certo, Maria Grazia ; Iezzi, Simona ; De Nicola, Francesca ; Catena, Valeria ; Floridi, Aristide ; Chessa, Luciana ; Passananti, Claudio ; Cundari, Enrico ; Fanciulli, Maurizio. / Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 32. pp. 23348-23357.

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abstract = "Background: Che-1 is an RNA polymerase II-binding protein involved in gene transcription, cell proliferation, and DNA damage response. Results: Che-1 localizes at interphase centrosomes. Che-1 inhibition abolishes Chk1 localization at centrosomes, advancing entry into mitosis. Conclusion: Che-1 acts like an upstream regulator of Chk1 centrosomal functions. Significance: Che-1 inhibition might potentiate tumor cell sensitivity to antimitotic drugs.",

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AU - Iezzi, Simona

AU - De Nicola, Francesca

AU - Catena, Valeria

AU - Floridi, Aristide

AU - Chessa, Luciana

AU - Passananti, Claudio

AU - Cundari, Enrico

AU - Fanciulli, Maurizio

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