Cephalic-phase insulin and glucagon release in normal subjects and in patients receiving pancreas transplantation

Antonio Secchi, Rossana Caldara, Andrea Caumo, Lucilla D. Monti, Doretta Bonfatti, Valerio Di Carlo, Guido Pozza

Research output: Contribution to journalArticle

Abstract

The aim of the study was to evaluate whether the cephalic phase of insulin release is still present in patients submitted to simultaneous kidney and pancreas transplantation. Subjects were five kidney-pancreas-transplanted patients (group P) and five control (group C). The experimental protocol lasted 30 minutes, and blood samples were collected at 1-minute intervals. After a 20-minute period of steady-state fasting (premeal period), subjects received a palatable standard meal (pizza). Samples were collected over the subsequent 10 minutes (meal period). No evidence of an increase in serum free insulin, serum C-peptide, and plasma glucagon during food ingestion was observed in group P whereas the test was effective in eliciting cephalic-phase insulin and glucagon release in group C. Gastric inhibitory polypeptide and somatostatin did not show any variation during the test in both groups. In conclusion, the absence of cephalic-phase insulin and glucagon release in group P could be explained by denervation of the grafted pancreas. This early alteration could contribute to the impairment in glucose tolerance frequently observed in successfully pancreas-transplanted patients.

Original languageEnglish
Pages (from-to)1153-1158
Number of pages6
JournalMetabolism
Volume44
Issue number9
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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