Abstract
Purpose To compare the antibiotic prophylaxis based on quinolone administered orally with a combination of cephalosporin administered periprostatically and a fluoroquinolone orally, in terms of post-prostate bioptic infectious complication rates in those men undergoing transrectal ultrasound-guided prostate biopsy (TRUS gpb). Methods: In a prospective, randomized, double-blind study, 150 consecutive patients were randomized to receive 10 ml lidocaine 1 % in Group A and ceftriaxone 1 g diluted in a solution of 10 ml of lidocaine 1 % in Group B, before TRUS gpb. All signed the informed consent. The men were asked to grade the pain using a ten points visual analogue scale close after TRUS gpb. In a telephone interview at 3 and 6 days, they were asked about early and late complications, assessing rectal bleeding, urinary retection, fewer, haematuria, urethral bleeding and hematospermia. Results: Of the 150 men enrolled, 135, 70 in GroupsA and 65 in Group B, completed the study. Four men (5.7 %) in Group A developed sepsis after TRUS gpb requiring hospital admission and intravenous antibiotic treatment, while none in Group B. Escherichia coli was the only organism isolated. The mean pain score was 2.76 ± 1.69 and 1.73 ± 1.26 for Group A and B, respectively (p = 0.08). Complications, evaluated at 3 and 6 days after the procedure through a telephone interview, were similar in both Groups. Conclusions The antibiotic prophylaxis based on the combination of ceftriaxone administered periprostatically and ciprofloxacin orally is able to offer a best control on infections caused by fluoroquinoloneresistant E. coli.
| Original language | English |
|---|---|
| Pages (from-to) | 1065-1070 |
| Number of pages | 6 |
| Journal | International Urology and Nephrology |
| Volume | 44 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2012 |
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Keywords
- Antibiotics prophylaxis
- Local anaesthesia
- Prostatic biopsy
- Sepsis
ASJC Scopus subject areas
- Nephrology
- Urology
Cite this
Cephalosporins periprostatic injection : Are really effective on infections following prostate biopsy? / Pace, Gianna; Carmignani, Luca; Marenghi, Carlo; Mombelli, Gabriella; Bozzini, Giorgio.
In: International Urology and Nephrology, Vol. 44, No. 4, 08.2012, p. 1065-1070.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cephalosporins periprostatic injection
T2 - Are really effective on infections following prostate biopsy?
AU - Pace, Gianna
AU - Carmignani, Luca
AU - Marenghi, Carlo
AU - Mombelli, Gabriella
AU - Bozzini, Giorgio
PY - 2012/8
Y1 - 2012/8
N2 - Purpose To compare the antibiotic prophylaxis based on quinolone administered orally with a combination of cephalosporin administered periprostatically and a fluoroquinolone orally, in terms of post-prostate bioptic infectious complication rates in those men undergoing transrectal ultrasound-guided prostate biopsy (TRUS gpb). Methods: In a prospective, randomized, double-blind study, 150 consecutive patients were randomized to receive 10 ml lidocaine 1 % in Group A and ceftriaxone 1 g diluted in a solution of 10 ml of lidocaine 1 % in Group B, before TRUS gpb. All signed the informed consent. The men were asked to grade the pain using a ten points visual analogue scale close after TRUS gpb. In a telephone interview at 3 and 6 days, they were asked about early and late complications, assessing rectal bleeding, urinary retection, fewer, haematuria, urethral bleeding and hematospermia. Results: Of the 150 men enrolled, 135, 70 in GroupsA and 65 in Group B, completed the study. Four men (5.7 %) in Group A developed sepsis after TRUS gpb requiring hospital admission and intravenous antibiotic treatment, while none in Group B. Escherichia coli was the only organism isolated. The mean pain score was 2.76 ± 1.69 and 1.73 ± 1.26 for Group A and B, respectively (p = 0.08). Complications, evaluated at 3 and 6 days after the procedure through a telephone interview, were similar in both Groups. Conclusions The antibiotic prophylaxis based on the combination of ceftriaxone administered periprostatically and ciprofloxacin orally is able to offer a best control on infections caused by fluoroquinoloneresistant E. coli.
AB - Purpose To compare the antibiotic prophylaxis based on quinolone administered orally with a combination of cephalosporin administered periprostatically and a fluoroquinolone orally, in terms of post-prostate bioptic infectious complication rates in those men undergoing transrectal ultrasound-guided prostate biopsy (TRUS gpb). Methods: In a prospective, randomized, double-blind study, 150 consecutive patients were randomized to receive 10 ml lidocaine 1 % in Group A and ceftriaxone 1 g diluted in a solution of 10 ml of lidocaine 1 % in Group B, before TRUS gpb. All signed the informed consent. The men were asked to grade the pain using a ten points visual analogue scale close after TRUS gpb. In a telephone interview at 3 and 6 days, they were asked about early and late complications, assessing rectal bleeding, urinary retection, fewer, haematuria, urethral bleeding and hematospermia. Results: Of the 150 men enrolled, 135, 70 in GroupsA and 65 in Group B, completed the study. Four men (5.7 %) in Group A developed sepsis after TRUS gpb requiring hospital admission and intravenous antibiotic treatment, while none in Group B. Escherichia coli was the only organism isolated. The mean pain score was 2.76 ± 1.69 and 1.73 ± 1.26 for Group A and B, respectively (p = 0.08). Complications, evaluated at 3 and 6 days after the procedure through a telephone interview, were similar in both Groups. Conclusions The antibiotic prophylaxis based on the combination of ceftriaxone administered periprostatically and ciprofloxacin orally is able to offer a best control on infections caused by fluoroquinoloneresistant E. coli.
KW - Antibiotics prophylaxis
KW - Local anaesthesia
KW - Prostatic biopsy
KW - Sepsis
UR - http://www.scopus.com/inward/record.url?scp=84867898554&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867898554&partnerID=8YFLogxK
U2 - 10.1007/s11255-012-0160-x
DO - 10.1007/s11255-012-0160-x
M3 - Article
C2 - 22434340
AN - SCOPUS:84867898554
VL - 44
SP - 1065
EP - 1070
JO - International Urology and Nephrology
JF - International Urology and Nephrology
SN - 0301-1623
IS - 4
ER -