Cephalosporins periprostatic injection: Are really effective on infections following prostate biopsy?

Gianna Pace, Luca Carmignani, Carlo Marenghi, Gabriella Mombelli, Giorgio Bozzini

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose To compare the antibiotic prophylaxis based on quinolone administered orally with a combination of cephalosporin administered periprostatically and a fluoroquinolone orally, in terms of post-prostate bioptic infectious complication rates in those men undergoing transrectal ultrasound-guided prostate biopsy (TRUS gpb). Methods: In a prospective, randomized, double-blind study, 150 consecutive patients were randomized to receive 10 ml lidocaine 1 % in Group A and ceftriaxone 1 g diluted in a solution of 10 ml of lidocaine 1 % in Group B, before TRUS gpb. All signed the informed consent. The men were asked to grade the pain using a ten points visual analogue scale close after TRUS gpb. In a telephone interview at 3 and 6 days, they were asked about early and late complications, assessing rectal bleeding, urinary retection, fewer, haematuria, urethral bleeding and hematospermia. Results: Of the 150 men enrolled, 135, 70 in GroupsA and 65 in Group B, completed the study. Four men (5.7 %) in Group A developed sepsis after TRUS gpb requiring hospital admission and intravenous antibiotic treatment, while none in Group B. Escherichia coli was the only organism isolated. The mean pain score was 2.76 ± 1.69 and 1.73 ± 1.26 for Group A and B, respectively (p = 0.08). Complications, evaluated at 3 and 6 days after the procedure through a telephone interview, were similar in both Groups. Conclusions The antibiotic prophylaxis based on the combination of ceftriaxone administered periprostatically and ciprofloxacin orally is able to offer a best control on infections caused by fluoroquinoloneresistant E. coli.

Original languageEnglish
Pages (from-to)1065-1070
Number of pages6
JournalInternational Urology and Nephrology
Volume44
Issue number4
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Cephalosporins
Prostate
Biopsy
Injections
Infection
Antibiotic Prophylaxis
Ceftriaxone
Lidocaine
Hemospermia
Interviews
Hemorrhage
Escherichia coli
Pain
Quinolones
Fluoroquinolones
Hematuria
Ciprofloxacin
Infection Control
Informed Consent
Visual Analog Scale

Keywords

  • Antibiotics prophylaxis
  • Local anaesthesia
  • Prostatic biopsy
  • Sepsis

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Cephalosporins periprostatic injection : Are really effective on infections following prostate biopsy? / Pace, Gianna; Carmignani, Luca; Marenghi, Carlo; Mombelli, Gabriella; Bozzini, Giorgio.

In: International Urology and Nephrology, Vol. 44, No. 4, 08.2012, p. 1065-1070.

Research output: Contribution to journalArticle

Pace, Gianna ; Carmignani, Luca ; Marenghi, Carlo ; Mombelli, Gabriella ; Bozzini, Giorgio. / Cephalosporins periprostatic injection : Are really effective on infections following prostate biopsy?. In: International Urology and Nephrology. 2012 ; Vol. 44, No. 4. pp. 1065-1070.
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