Cereal fiber intake may reduce risk of gastric adenocarcinomas: The EPIC-EURGAST study

M. A. Mendez, Guillem Pera, Antonio Agudo, H. Bas Bueno-de-Mesquita, Domenico Palli, Heiner Boeing, Fátima Carneiro, Franco Berrino, Carlotta Sacerdote, Rosario Tumino, Salvatore Panico, Göran Berglund, Jonas Manjer, Ingegerd Johansson, Roger Stenling, Carmen Martinez, Miren Dorronsoro, Aurelio Barricarte, María J. Tormo, José R. QuirosNaomi Allen, Timothy J. Key, Sheila Bingham, Jakob Linseisen, Rudolf Kaaks, Kim Overvad, Majken Jensen, Anja Olsen, Anne Tjønneland, Petra H M Peeters, Mattijs E. Numans, Marga C. Ocké, Franco̧ise Clavel-Chapelon, Marie Christine Boutron-Ruault, Antonia Trichopoulou, Eiliv Lund, Nadia Slimani, Mazda Jenab, Pietro Ferrari, Elio Riboli, Carlos A. González

Research output: Contribution to journalArticle

Abstract

Numerous case-control studies suggest dietary fiber may reduce risk of gastric cancer, but this has not been confirmed prospectively. A previous case-control study reported reduced risk of gastric cardia adenocarcinomas associated with cereal fiber, but not with fruit or vegetable fiber. To date, different food sources of fiber have not been examined with respect to noncardia tumors or diverse histologic sub-types. This study prospectively examines associations between fiber from different food sources and incident gastric adenocarcinomas (GC) among more than 435,000 subjects from 10 countries participating in the European Prospective Investigation into Cancer and Nutrition study. Subjects aged 25-70 years completed dietary questionnaires in 1992-98, and were followed up for a median of 6.7 years. About 312 incident GCs were observed. The relative risk of GC was estimated based on cohort-wide sex-specific fiber intake quartiles using proportional hazards models to estimate hazards ratios (HRs) and 95% confidence intervals (CIs). Intakes of cereal fiber, but not total, fruit or vegetable fiber, were associated with reduced GC risk [adjusted HR for the highest vs. lowest quartile of cereal fiber 0.69, 0.48-0.99]. There was a strong inverse association for diffuse [HR 0.43, 0.22-0.86], but not intestinal type [HR 0.98, 0.54-1.80] tumors. Associations for cardia vs. noncardia tumors were similar to those for overall GC, although cardia associations did not reach significance. Cereal fiber consumption may help to reduce risk of GC, particularly diffuse type tumors. Further study on different food sources of fiber in relation to GC risk is warranted to confirm these relationships.

Original languageEnglish
Pages (from-to)1618-1623
Number of pages6
JournalInternational Journal of Cancer
Volume121
Issue number7
DOIs
Publication statusPublished - Oct 1 2007

Fingerprint

Stomach
Adenocarcinoma
Cardia
Neoplasms
Food
Vegetables
Case-Control Studies
Fruit
Dietary Fiber
Edible Grain
Proportional Hazards Models
Stomach Neoplasms
Confidence Intervals

Keywords

  • Cereal fiber
  • Cohort study
  • Gastric cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mendez, M. A., Pera, G., Agudo, A., Bas Bueno-de-Mesquita, H., Palli, D., Boeing, H., ... González, C. A. (2007). Cereal fiber intake may reduce risk of gastric adenocarcinomas: The EPIC-EURGAST study. International Journal of Cancer, 121(7), 1618-1623. https://doi.org/10.1002/ijc.22896

Cereal fiber intake may reduce risk of gastric adenocarcinomas : The EPIC-EURGAST study. / Mendez, M. A.; Pera, Guillem; Agudo, Antonio; Bas Bueno-de-Mesquita, H.; Palli, Domenico; Boeing, Heiner; Carneiro, Fátima; Berrino, Franco; Sacerdote, Carlotta; Tumino, Rosario; Panico, Salvatore; Berglund, Göran; Manjer, Jonas; Johansson, Ingegerd; Stenling, Roger; Martinez, Carmen; Dorronsoro, Miren; Barricarte, Aurelio; Tormo, María J.; Quiros, José R.; Allen, Naomi; Key, Timothy J.; Bingham, Sheila; Linseisen, Jakob; Kaaks, Rudolf; Overvad, Kim; Jensen, Majken; Olsen, Anja; Tjønneland, Anne; Peeters, Petra H M; Numans, Mattijs E.; Ocké, Marga C.; Clavel-Chapelon, Franco̧ise; Boutron-Ruault, Marie Christine; Trichopoulou, Antonia; Lund, Eiliv; Slimani, Nadia; Jenab, Mazda; Ferrari, Pietro; Riboli, Elio; González, Carlos A.

In: International Journal of Cancer, Vol. 121, No. 7, 01.10.2007, p. 1618-1623.

Research output: Contribution to journalArticle

Mendez, MA, Pera, G, Agudo, A, Bas Bueno-de-Mesquita, H, Palli, D, Boeing, H, Carneiro, F, Berrino, F, Sacerdote, C, Tumino, R, Panico, S, Berglund, G, Manjer, J, Johansson, I, Stenling, R, Martinez, C, Dorronsoro, M, Barricarte, A, Tormo, MJ, Quiros, JR, Allen, N, Key, TJ, Bingham, S, Linseisen, J, Kaaks, R, Overvad, K, Jensen, M, Olsen, A, Tjønneland, A, Peeters, PHM, Numans, ME, Ocké, MC, Clavel-Chapelon, F, Boutron-Ruault, MC, Trichopoulou, A, Lund, E, Slimani, N, Jenab, M, Ferrari, P, Riboli, E & González, CA 2007, 'Cereal fiber intake may reduce risk of gastric adenocarcinomas: The EPIC-EURGAST study', International Journal of Cancer, vol. 121, no. 7, pp. 1618-1623. https://doi.org/10.1002/ijc.22896
Mendez MA, Pera G, Agudo A, Bas Bueno-de-Mesquita H, Palli D, Boeing H et al. Cereal fiber intake may reduce risk of gastric adenocarcinomas: The EPIC-EURGAST study. International Journal of Cancer. 2007 Oct 1;121(7):1618-1623. https://doi.org/10.1002/ijc.22896
Mendez, M. A. ; Pera, Guillem ; Agudo, Antonio ; Bas Bueno-de-Mesquita, H. ; Palli, Domenico ; Boeing, Heiner ; Carneiro, Fátima ; Berrino, Franco ; Sacerdote, Carlotta ; Tumino, Rosario ; Panico, Salvatore ; Berglund, Göran ; Manjer, Jonas ; Johansson, Ingegerd ; Stenling, Roger ; Martinez, Carmen ; Dorronsoro, Miren ; Barricarte, Aurelio ; Tormo, María J. ; Quiros, José R. ; Allen, Naomi ; Key, Timothy J. ; Bingham, Sheila ; Linseisen, Jakob ; Kaaks, Rudolf ; Overvad, Kim ; Jensen, Majken ; Olsen, Anja ; Tjønneland, Anne ; Peeters, Petra H M ; Numans, Mattijs E. ; Ocké, Marga C. ; Clavel-Chapelon, Franco̧ise ; Boutron-Ruault, Marie Christine ; Trichopoulou, Antonia ; Lund, Eiliv ; Slimani, Nadia ; Jenab, Mazda ; Ferrari, Pietro ; Riboli, Elio ; González, Carlos A. / Cereal fiber intake may reduce risk of gastric adenocarcinomas : The EPIC-EURGAST study. In: International Journal of Cancer. 2007 ; Vol. 121, No. 7. pp. 1618-1623.
@article{1d743156fe054f91988fda022237ab2d,
title = "Cereal fiber intake may reduce risk of gastric adenocarcinomas: The EPIC-EURGAST study",
abstract = "Numerous case-control studies suggest dietary fiber may reduce risk of gastric cancer, but this has not been confirmed prospectively. A previous case-control study reported reduced risk of gastric cardia adenocarcinomas associated with cereal fiber, but not with fruit or vegetable fiber. To date, different food sources of fiber have not been examined with respect to noncardia tumors or diverse histologic sub-types. This study prospectively examines associations between fiber from different food sources and incident gastric adenocarcinomas (GC) among more than 435,000 subjects from 10 countries participating in the European Prospective Investigation into Cancer and Nutrition study. Subjects aged 25-70 years completed dietary questionnaires in 1992-98, and were followed up for a median of 6.7 years. About 312 incident GCs were observed. The relative risk of GC was estimated based on cohort-wide sex-specific fiber intake quartiles using proportional hazards models to estimate hazards ratios (HRs) and 95{\%} confidence intervals (CIs). Intakes of cereal fiber, but not total, fruit or vegetable fiber, were associated with reduced GC risk [adjusted HR for the highest vs. lowest quartile of cereal fiber 0.69, 0.48-0.99]. There was a strong inverse association for diffuse [HR 0.43, 0.22-0.86], but not intestinal type [HR 0.98, 0.54-1.80] tumors. Associations for cardia vs. noncardia tumors were similar to those for overall GC, although cardia associations did not reach significance. Cereal fiber consumption may help to reduce risk of GC, particularly diffuse type tumors. Further study on different food sources of fiber in relation to GC risk is warranted to confirm these relationships.",
keywords = "Cereal fiber, Cohort study, Gastric cancer",
author = "Mendez, {M. A.} and Guillem Pera and Antonio Agudo and {Bas Bueno-de-Mesquita}, H. and Domenico Palli and Heiner Boeing and F{\'a}tima Carneiro and Franco Berrino and Carlotta Sacerdote and Rosario Tumino and Salvatore Panico and G{\"o}ran Berglund and Jonas Manjer and Ingegerd Johansson and Roger Stenling and Carmen Martinez and Miren Dorronsoro and Aurelio Barricarte and Tormo, {Mar{\'i}a J.} and Quiros, {Jos{\'e} R.} and Naomi Allen and Key, {Timothy J.} and Sheila Bingham and Jakob Linseisen and Rudolf Kaaks and Kim Overvad and Majken Jensen and Anja Olsen and Anne Tj{\o}nneland and Peeters, {Petra H M} and Numans, {Mattijs E.} and Ock{\'e}, {Marga C.} and Franco̧ise Clavel-Chapelon and Boutron-Ruault, {Marie Christine} and Antonia Trichopoulou and Eiliv Lund and Nadia Slimani and Mazda Jenab and Pietro Ferrari and Elio Riboli and Gonz{\'a}lez, {Carlos A.}",
year = "2007",
month = "10",
day = "1",
doi = "10.1002/ijc.22896",
language = "English",
volume = "121",
pages = "1618--1623",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "7",

}

TY - JOUR

T1 - Cereal fiber intake may reduce risk of gastric adenocarcinomas

T2 - The EPIC-EURGAST study

AU - Mendez, M. A.

AU - Pera, Guillem

AU - Agudo, Antonio

AU - Bas Bueno-de-Mesquita, H.

AU - Palli, Domenico

AU - Boeing, Heiner

AU - Carneiro, Fátima

AU - Berrino, Franco

AU - Sacerdote, Carlotta

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Berglund, Göran

AU - Manjer, Jonas

AU - Johansson, Ingegerd

AU - Stenling, Roger

AU - Martinez, Carmen

AU - Dorronsoro, Miren

AU - Barricarte, Aurelio

AU - Tormo, María J.

AU - Quiros, José R.

AU - Allen, Naomi

AU - Key, Timothy J.

AU - Bingham, Sheila

AU - Linseisen, Jakob

AU - Kaaks, Rudolf

AU - Overvad, Kim

AU - Jensen, Majken

AU - Olsen, Anja

AU - Tjønneland, Anne

AU - Peeters, Petra H M

AU - Numans, Mattijs E.

AU - Ocké, Marga C.

AU - Clavel-Chapelon, Franco̧ise

AU - Boutron-Ruault, Marie Christine

AU - Trichopoulou, Antonia

AU - Lund, Eiliv

AU - Slimani, Nadia

AU - Jenab, Mazda

AU - Ferrari, Pietro

AU - Riboli, Elio

AU - González, Carlos A.

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Numerous case-control studies suggest dietary fiber may reduce risk of gastric cancer, but this has not been confirmed prospectively. A previous case-control study reported reduced risk of gastric cardia adenocarcinomas associated with cereal fiber, but not with fruit or vegetable fiber. To date, different food sources of fiber have not been examined with respect to noncardia tumors or diverse histologic sub-types. This study prospectively examines associations between fiber from different food sources and incident gastric adenocarcinomas (GC) among more than 435,000 subjects from 10 countries participating in the European Prospective Investigation into Cancer and Nutrition study. Subjects aged 25-70 years completed dietary questionnaires in 1992-98, and were followed up for a median of 6.7 years. About 312 incident GCs were observed. The relative risk of GC was estimated based on cohort-wide sex-specific fiber intake quartiles using proportional hazards models to estimate hazards ratios (HRs) and 95% confidence intervals (CIs). Intakes of cereal fiber, but not total, fruit or vegetable fiber, were associated with reduced GC risk [adjusted HR for the highest vs. lowest quartile of cereal fiber 0.69, 0.48-0.99]. There was a strong inverse association for diffuse [HR 0.43, 0.22-0.86], but not intestinal type [HR 0.98, 0.54-1.80] tumors. Associations for cardia vs. noncardia tumors were similar to those for overall GC, although cardia associations did not reach significance. Cereal fiber consumption may help to reduce risk of GC, particularly diffuse type tumors. Further study on different food sources of fiber in relation to GC risk is warranted to confirm these relationships.

AB - Numerous case-control studies suggest dietary fiber may reduce risk of gastric cancer, but this has not been confirmed prospectively. A previous case-control study reported reduced risk of gastric cardia adenocarcinomas associated with cereal fiber, but not with fruit or vegetable fiber. To date, different food sources of fiber have not been examined with respect to noncardia tumors or diverse histologic sub-types. This study prospectively examines associations between fiber from different food sources and incident gastric adenocarcinomas (GC) among more than 435,000 subjects from 10 countries participating in the European Prospective Investigation into Cancer and Nutrition study. Subjects aged 25-70 years completed dietary questionnaires in 1992-98, and were followed up for a median of 6.7 years. About 312 incident GCs were observed. The relative risk of GC was estimated based on cohort-wide sex-specific fiber intake quartiles using proportional hazards models to estimate hazards ratios (HRs) and 95% confidence intervals (CIs). Intakes of cereal fiber, but not total, fruit or vegetable fiber, were associated with reduced GC risk [adjusted HR for the highest vs. lowest quartile of cereal fiber 0.69, 0.48-0.99]. There was a strong inverse association for diffuse [HR 0.43, 0.22-0.86], but not intestinal type [HR 0.98, 0.54-1.80] tumors. Associations for cardia vs. noncardia tumors were similar to those for overall GC, although cardia associations did not reach significance. Cereal fiber consumption may help to reduce risk of GC, particularly diffuse type tumors. Further study on different food sources of fiber in relation to GC risk is warranted to confirm these relationships.

KW - Cereal fiber

KW - Cohort study

KW - Gastric cancer

UR - http://www.scopus.com/inward/record.url?scp=34548284483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548284483&partnerID=8YFLogxK

U2 - 10.1002/ijc.22896

DO - 10.1002/ijc.22896

M3 - Article

C2 - 17582605

AN - SCOPUS:34548284483

VL - 121

SP - 1618

EP - 1623

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 7

ER -