Cerebellar activity switches hemispheres with cerebral recovery in aphasia

Lisa Tabor Connor, Tiffany DeShazo Braby, Abraham Z. Snyder, Christopher Lewis, Valeria Blasi, Maurizio Corbetta

Research output: Contribution to journalArticle

Abstract

The right postero-lateral cerebellum participates with the left frontal lobe in the selection and production of words. Using fMRI, we examined whether cerebellar activity switches hemispheres in parallel with recruitment of putative compensatory right homologous frontal regions in post-stroke aphasia. Re-examining the data of Blasi et al. [Blasi, V., Young, A. C., Tansy, A. P., Petersen, S. E., Snyder, A. Z., & Corbetta, M. (2002). Word retrieval learning modulates right frontal cortex in patients with left frontal damage. Neuron, 36(1), 159-170], we asked: (1) if activity in the right cerebellum was disrupted by a left frontal lesion, (2) if activity switched to the left cerebellum, and (3) if activity in the left cerebellum was modulated by learning, as was right frontal cortex. Fourteen age-matched controls and eight mildly aphasic stroke patients participated. Aphasic participants all had lesions due to unilateral left hemisphere stroke at or near Broca's area. Subjects silently performed a word stem completion task with either novel or repeated items. Activity in right cerebellum of aphasic individuals was minimal and was not modulated by learning, as for controls. However, we observed robust learning-related attenuation of the BOLD signal in the left postero-lateral cerebellum consistent with learning-related effects in right frontal cortex. These findings support the hypothesis that right frontal and left cerebellar circuits are likely to be functionally relevant to recovered/residual verbal function.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalNeuropsychologia
Volume44
Issue number2
DOIs
Publication statusPublished - 2006

Keywords

  • Aphasia
  • Cerebellum
  • fMRI
  • Language
  • Learning
  • Recovery
  • Stroke

ASJC Scopus subject areas

  • Arts and Humanities(all)
  • Behavioral Neuroscience
  • Psychology(all)
  • Neuropsychology and Physiological Psychology
  • Health Professions(all)

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  • Cite this

    Connor, L. T., Braby, T. D., Snyder, A. Z., Lewis, C., Blasi, V., & Corbetta, M. (2006). Cerebellar activity switches hemispheres with cerebral recovery in aphasia. Neuropsychologia, 44(2), 171-177. https://doi.org/10.1016/j.neuropsychologia.2005.05.019