Cerebellar control of cortico-striatal LTD

Silvia Rossi, Giorgia Mataluni, Paola De Bartolo, Chiara Prosperetti, Francesca Foti, Valentina De Chiara, Alessandra Musella, Laura Mandolesi, Giorgio Bernardi, Diego Centonze, Laura Petrosini

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: Recent anatomical studies showed the presence of cerebellar and basal ganglia connections. It is thus conceivable that the cerebellum may influence the striatal synaptic transmission in general, and synaptic plasticity in particular. Methods: In the present neurophysiological investigation in brain slices, we studied striatal long-term depression (LTD), a crucial form of synaptic plasticity involved in motor learning after cerebellar lesions in rats. Results: Striatal LTD was fully abolished in the left striatum of rats with right hemicerebellectomy recorded 3 and 7 days following surgery, when the motor deficits were at their peak. Fifteen days after the hemicerebellectomy, rats had partially compensated their motor deficits and high-frequency stimulation of excitatory synapses in the left striatum was able to induce a stable LTD. Striatal plasticity was conversely normal ipsilaterally to cerebellar lesions, as well as in the right and left striatum of sham-operated animals. Conclusions: These data show that the cerebellum controls striatal synaptic plasticity, supporting the notion that the two structures operate in conjunction during motor learning.

Original languageEnglish
Pages (from-to)475-480
Number of pages6
JournalRestorative Neurology and Neuroscience
Volume26
Issue number6
Publication statusPublished - 2008

Fingerprint

Corpus Striatum
Neuronal Plasticity
Depression
Cerebellum
Learning
Basal Ganglia
Ambulatory Surgical Procedures
Synaptic Transmission
Synapses
Brain

Keywords

  • EPSP
  • long-term depression
  • motor recovery
  • rat
  • synaptic plasticity

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Rossi, S., Mataluni, G., De Bartolo, P., Prosperetti, C., Foti, F., De Chiara, V., ... Petrosini, L. (2008). Cerebellar control of cortico-striatal LTD. Restorative Neurology and Neuroscience, 26(6), 475-480.

Cerebellar control of cortico-striatal LTD. / Rossi, Silvia; Mataluni, Giorgia; De Bartolo, Paola; Prosperetti, Chiara; Foti, Francesca; De Chiara, Valentina; Musella, Alessandra; Mandolesi, Laura; Bernardi, Giorgio; Centonze, Diego; Petrosini, Laura.

In: Restorative Neurology and Neuroscience, Vol. 26, No. 6, 2008, p. 475-480.

Research output: Contribution to journalArticle

Rossi, S, Mataluni, G, De Bartolo, P, Prosperetti, C, Foti, F, De Chiara, V, Musella, A, Mandolesi, L, Bernardi, G, Centonze, D & Petrosini, L 2008, 'Cerebellar control of cortico-striatal LTD', Restorative Neurology and Neuroscience, vol. 26, no. 6, pp. 475-480.
Rossi S, Mataluni G, De Bartolo P, Prosperetti C, Foti F, De Chiara V et al. Cerebellar control of cortico-striatal LTD. Restorative Neurology and Neuroscience. 2008;26(6):475-480.
Rossi, Silvia ; Mataluni, Giorgia ; De Bartolo, Paola ; Prosperetti, Chiara ; Foti, Francesca ; De Chiara, Valentina ; Musella, Alessandra ; Mandolesi, Laura ; Bernardi, Giorgio ; Centonze, Diego ; Petrosini, Laura. / Cerebellar control of cortico-striatal LTD. In: Restorative Neurology and Neuroscience. 2008 ; Vol. 26, No. 6. pp. 475-480.
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