Abstract
Prostate cancer (PCa) is the most frequent cancer among men in many developing countries, and the second leading cause of cancer-related death in men. A genetic component has been implicated in PCa onset and development. The cerebellar degeneration-related autoantigen 1 (CDR1) gene, mapping in Xq26-q27.2, is expressed in cerebrum, cerebellum, heart, lung, liver, and kidney. In addition, CDR1 expression has been detected in neuroblastoma, renal carcinoma cell lines, and other cancer cell lines.
In this study, we investigated the expression of the CDR1 gene in the LNCaP and PC-3 PCa cell lines, and in the PNT1A normal prostate cell line. CDR1 mRNA expression was evaluated by qRT-PCR. We found that the CDR1 gene was overexpressed in the LNCaP and PC-3 PCa cell lines as compared with the PNT1A normal prostate cell line. These data suggest that CDR1 could be a new biomarker for PCa identification.
| Original language | English |
|---|---|
| Pages (from-to) | e288-e290 |
| Journal | International Journal of Biological Markers |
| Volume | 29 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 1 2014 |
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Keywords
- CDR1 gene
- mRNA
- Prostate cancer
- qRT-PCR
ASJC Scopus subject areas
- Clinical Biochemistry
- Cancer Research
- Oncology
- Pathology and Forensic Medicine
Cite this
Cerebellar degeneration-related autoantigen 1 (CDR1) gene expression in prostate cancer cell lines. / Salemi, Michele; Fraggetta, Filippo; Galia, Antonio; Pepe, Pietro; Cimino, Laura; Condorelli, Rosita A.; Calogero, Aldo E.
In: International Journal of Biological Markers, Vol. 29, No. 3, 01.07.2014, p. e288-e290.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebellar degeneration-related autoantigen 1 (CDR1) gene expression in prostate cancer cell lines
AU - Salemi, Michele
AU - Fraggetta, Filippo
AU - Galia, Antonio
AU - Pepe, Pietro
AU - Cimino, Laura
AU - Condorelli, Rosita A.
AU - Calogero, Aldo E.
PY - 2014/7/1
Y1 - 2014/7/1
N2 - Prostate cancer (PCa) is the most frequent cancer among men in many developing countries, and the second leading cause of cancer-related death in men. A genetic component has been implicated in PCa onset and development. The cerebellar degeneration-related autoantigen 1 (CDR1) gene, mapping in Xq26-q27.2, is expressed in cerebrum, cerebellum, heart, lung, liver, and kidney. In addition, CDR1 expression has been detected in neuroblastoma, renal carcinoma cell lines, and other cancer cell lines.In this study, we investigated the expression of the CDR1 gene in the LNCaP and PC-3 PCa cell lines, and in the PNT1A normal prostate cell line. CDR1 mRNA expression was evaluated by qRT-PCR. We found that the CDR1 gene was overexpressed in the LNCaP and PC-3 PCa cell lines as compared with the PNT1A normal prostate cell line. These data suggest that CDR1 could be a new biomarker for PCa identification.
AB - Prostate cancer (PCa) is the most frequent cancer among men in many developing countries, and the second leading cause of cancer-related death in men. A genetic component has been implicated in PCa onset and development. The cerebellar degeneration-related autoantigen 1 (CDR1) gene, mapping in Xq26-q27.2, is expressed in cerebrum, cerebellum, heart, lung, liver, and kidney. In addition, CDR1 expression has been detected in neuroblastoma, renal carcinoma cell lines, and other cancer cell lines.In this study, we investigated the expression of the CDR1 gene in the LNCaP and PC-3 PCa cell lines, and in the PNT1A normal prostate cell line. CDR1 mRNA expression was evaluated by qRT-PCR. We found that the CDR1 gene was overexpressed in the LNCaP and PC-3 PCa cell lines as compared with the PNT1A normal prostate cell line. These data suggest that CDR1 could be a new biomarker for PCa identification.
KW - CDR1 gene
KW - mRNA
KW - Prostate cancer
KW - qRT-PCR
UR - http://www.scopus.com/inward/record.url?scp=84907479271&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907479271&partnerID=8YFLogxK
U2 - 10.5301/jbm.5000062
DO - 10.5301/jbm.5000062
M3 - Article
C2 - 24366849
AN - SCOPUS:84907479271
VL - 29
SP - e288-e290
JO - International Journal of Biological Markers
JF - International Journal of Biological Markers
SN - 0393-6155
IS - 3
ER -