TY - JOUR
T1 - Cerebellar dentate nucleus functional connectivity with cerebral cortex in Alzheimer's disease and memory
T2 - a seed-based approach
AU - Olivito, Giusy
AU - Serra, Laura
AU - Marra, Camillo
AU - Di Domenico, Carlotta
AU - Caltagirone, Carlo
AU - Toniolo, Sofia
AU - Cercignani, Mara
AU - Leggio, Maria
AU - Bozzali, Marco
N1 - Funding Information:
This research was in part financially supported by Italian Ministry of Health , Italy (Linea di Ricerca Corrente: Neuroriabilitazione Cognitiva, Motoria e Neuroimmagini). Project Title: Ruolo del cervelletto nella patologia di Alzheimer a diverso stadio evolutivo.
Publisher Copyright:
© 2020 Elsevier Inc.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/5
Y1 - 2020/5
N2 - Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by specific patterns of gray and white matter damage and cognitive/behavioral manifestations. The cerebellum has also been implicated in the pathophysiology of AD. Because the cerebellum is known to have strong functional connectivity (FC) with associative cerebral cortex regions, it is possible to hypothesize that it is incorporated into intrinsic FC networks relevant to cognitive manifestation of AD. In the present study, the cerebellar dentate nucleus, the largest cerebellar nucleus and the major output channel to the cerebral cortex, was chosen as the region of interest to test potential cerebellocerebral FC alterations and correlations with patients' memory impairment in a group of patients with AD. Compared to controls, patients with AD showed an increase in FC between the dentate nucleus and regions of the lateral temporal lobe. This study demonstrates that lower memory performances in AD may be related to altered FC within specific cerebellocortical functional modules, thus suggesting the cerebellar contribution to AD pathophysiology and typical memory dysfunctions.
AB - Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by specific patterns of gray and white matter damage and cognitive/behavioral manifestations. The cerebellum has also been implicated in the pathophysiology of AD. Because the cerebellum is known to have strong functional connectivity (FC) with associative cerebral cortex regions, it is possible to hypothesize that it is incorporated into intrinsic FC networks relevant to cognitive manifestation of AD. In the present study, the cerebellar dentate nucleus, the largest cerebellar nucleus and the major output channel to the cerebral cortex, was chosen as the region of interest to test potential cerebellocerebral FC alterations and correlations with patients' memory impairment in a group of patients with AD. Compared to controls, patients with AD showed an increase in FC between the dentate nucleus and regions of the lateral temporal lobe. This study demonstrates that lower memory performances in AD may be related to altered FC within specific cerebellocortical functional modules, thus suggesting the cerebellar contribution to AD pathophysiology and typical memory dysfunctions.
KW - Alzheimer's disease
KW - Cerebellum
KW - Dentate nucleus
KW - Functional connectivity
KW - Memory
KW - Resting-state fMRI
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U2 - 10.1016/j.neurobiolaging.2019.10.026
DO - 10.1016/j.neurobiolaging.2019.10.026
M3 - Article
C2 - 32081466
AN - SCOPUS:85079810097
VL - 89
SP - 32
EP - 40
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -