Cerebellar gaba levels and cognitive interference in parkinson’s disease and healthy comparators

Federica Piras, Daniela Vecchio, Francesca Assogna, Clelia Pellicano, Valentina Ciullo, Nerisa Banaj, Richard A.E. Edden, Francesco E. Pontieri, Fabrizio Piras, Gianfranco Spalletta

Research output: Contribution to journalArticlepeer-review


The neuroanatomical and molecular substrates for cognitive impairment in Parkinson Disease (PD) are far from clear. Evidence suggests a non-dopaminergic basis, and a crucial role for cerebellum in cognitive control in PD. We investigated whether a PD cognitive marker (response in-hibition) was differently controlled by g-amino butyric acid (GABA) and/or by glutamate-glutamine (Glx) levels in the cerebellum of idiopathic PD patients, and healthy comparators (HC). Magnetic resonance spectroscopy of GABA/Glx (MEGA-PRESS acquisition sequence) was performed at 3 Tesla, and response inhibition assessed by the Stroop Word-Color Test (SWCT) and the Wisconsin Card Sorting Test (WCST). Linear correlations between cerebellar GABA/Glx levels, SWCT time/error interference effects and WCST perseverative errors were performed to test differences between correlation coefficients in PD and HC. Results showed that higher levels of mean cerebellar GABA were associated to SWCT increased time and error interference effects in PD, and the contrary in HC. Such effect dissociated by hemisphere, while correlation coefficients differences were significant in both right and left cerebellum. We conclude that MRS measured levels of cerebellar GABA are related in PD patients with decreased efficiency in filtering task-irrelevant information. This is crucial for developing pharmacological treatments for PD to potentially preserve cognitive functioning.

Original languageEnglish
Article number16
Pages (from-to)1-15
Number of pages15
JournalJournal of Personalized Medicine
Issue number1
Publication statusPublished - Dec 2020


  • Cerebellum
  • Cognition
  • GABAergic signaling
  • MRS
  • Parkinson’s Disease
  • Response inhibition

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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