Cerebellar induced differential polyglot aphasia: A neurolinguistic and fMRI study

P Mariën, K van Dun, J Van Dormael, D Vandenborre, S Keulen, M Manto, J Verhoeven, J Abutalebi

Research output: Contribution to journalArticle

Abstract

Research has shown that linguistic functions in the bilingual brain are subserved by similar neural circuits as in monolinguals, but with extra-activity associated with cognitive and attentional control. Although a role for the right cerebellum in multilingual language processing has recently been acknowledged, a potential role of the left cerebellum remains largely unexplored. This paper reports the clinical and fMRI findings in a strongly right-handed (late) multilingual patient who developed differential polyglot aphasia, ataxic dysarthria and a selective decrease in executive function due to an ischemic stroke in the left cerebellum. fMRI revealed that lexical-semantic retrieval in the unaffected L1 was predominantly associated with activations in the left cortical areas (left prefrontal area and left postcentral gyrus), while naming in two affected non-native languages recruited a significantly larger bilateral functional network, including the cerebellum. It is hypothesized that the left cerebellar insult resulted in decreased right prefrontal hemisphere functioning due to a loss of cerebellar impulses through the cerebello-cerebral pathways. © 2017
Original languageEnglish
Pages (from-to)18-28
Number of pages11
JournalBrain and Language
Volume175
Issue number2
DOIs
Publication statusPublished - 2017

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Aphasia
speech disorder
Cerebellum
Magnetic Resonance Imaging
stroke
language
activation
brain
Language
semantics
Broca Aphasia
linguistics
Dysarthria
Somatosensory Cortex
Executive Function
Linguistics
Semantics
Stroke
Neurolinguistics
Polyglot

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Mariën, P., van Dun, K., Van Dormael, J., Vandenborre, D., Keulen, S., Manto, M., ... Abutalebi, J. (2017). Cerebellar induced differential polyglot aphasia: A neurolinguistic and fMRI study. Brain and Language, 175(2), 18-28. https://doi.org/10.1016/j.bandl.2017.09.001

Cerebellar induced differential polyglot aphasia: A neurolinguistic and fMRI study. / Mariën, P; van Dun, K; Van Dormael, J; Vandenborre, D; Keulen, S; Manto, M; Verhoeven, J; Abutalebi, J.

In: Brain and Language, Vol. 175, No. 2, 2017, p. 18-28.

Research output: Contribution to journalArticle

Mariën, P, van Dun, K, Van Dormael, J, Vandenborre, D, Keulen, S, Manto, M, Verhoeven, J & Abutalebi, J 2017, 'Cerebellar induced differential polyglot aphasia: A neurolinguistic and fMRI study', Brain and Language, vol. 175, no. 2, pp. 18-28. https://doi.org/10.1016/j.bandl.2017.09.001
Mariën P, van Dun K, Van Dormael J, Vandenborre D, Keulen S, Manto M et al. Cerebellar induced differential polyglot aphasia: A neurolinguistic and fMRI study. Brain and Language. 2017;175(2):18-28. https://doi.org/10.1016/j.bandl.2017.09.001
Mariën, P ; van Dun, K ; Van Dormael, J ; Vandenborre, D ; Keulen, S ; Manto, M ; Verhoeven, J ; Abutalebi, J. / Cerebellar induced differential polyglot aphasia: A neurolinguistic and fMRI study. In: Brain and Language. 2017 ; Vol. 175, No. 2. pp. 18-28.
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