Cerebellar metabolic involvement and its correlations with clinical parameters in vestibular neuritis

Marco Alessandrini, Alessandro Micarelli, Ernesto Bruno, Agostino Chiaravalloti, Barbara Di Pietro, Orazio Schillaci, Matteo Candidi, Johanna Öberg, Marco Pagani

Research output: Contribution to journalArticlepeer-review

Abstract

Although vestibular neuritis (VN) cortical models are described in the literature, there is lack of knowledge regarding the exclusive cerebellar involvement. The aim of the present study was to analyze, by [18F] fluorodeoxyglucose-positron emission tomography (FDGPET)/ computer tomography, regional cerebellar FDG uptake in eight right-handed VN patients (five females; three males; mean age 48 ± 7 years) during the first few days (PET0) and after 1 month (PET1) since symptoms onset. At both phases, patients underwent otoneurological examination and filled in a battery of validated questionnaires. Twenty-six cerebellar volumes of interest (VOI) were identified by the automated anatomical labeling library and normalized to thalamus FDG-PET uptake. Mean intensity within VOIs was calculated in both phases and processed by within-subjects ANOVA. A significantly lower (p

Original languageEnglish
Pages (from-to)1976-1985
Number of pages10
JournalJournal of Neurology
Volume261
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Anatomical automatic labeling
  • Cerebellum
  • PET/CT
  • Vertigo
  • Vestibular neuritis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Cerebellar metabolic involvement and its correlations with clinical parameters in vestibular neuritis'. Together they form a unique fingerprint.

Cite this