Cerebellar neurones: Differentiation and modulation of sensitivity to excitotoxic treatment

D. Mercanti, A. Angelini, MT Ciotti, ML Eboli, C. Galli, L. Battistini, D. Merlo, P. Calissano

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Abstract

The neurite outgrowth and adhesion complex (NOAC), isolated from rabbit sera has been dissociated in its major components by reverse-phase chromatography in HPLC by using a C18 column. SDS-PAGE analisys of the active fractions revealed the presence of three major bands of approximately 100, 70 and 50 kDa. Studies on the biological activity of NOAC were carried out on rat cerebellar granule cells. NOAC-cultured cells exhibit a marked resistance to excitotoxic stimuli carried by glutamate.

Original languageEnglish
JournalCytotechnology
Volume11
Issue number1 Supplement
DOIs
Publication statusPublished - Jan 1993

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ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Biotechnology

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