Cerebellum Proteomics addressing the cognitive deficit of rats perinatally exposed to the food-relevant polychlorinated biphenyl 138

Roberta Campagna, Laura Brunelli, Luisa Airoldi, Roberto Fanelli, Helen Hakansson, Rachel A. Heimeier, Patrick De Boever, Jordi Boix, Marta Llansola, Vicente Felipo, Roberta Pastorelli

Research output: Contribution to journalArticle

Abstract

Developmental exposure to polychlorinated biphenyls (PCBs) has been associated with cognitive deficits in humans and laboratory animals by mechanisms that remain unknown. Recently, it has been shown that developmental exposure to 2,2′,3,4,4′,5′-hexachlorobiphenyl (PCB138), a food-relevant PCB congener, decreases the learning ability of young rats. The aim of this study was to characterize the effect of perinatal exposure to PCB138 on the brain proteome profile in young rats in order to gain insight into the mechanisms underlying PCB138 neurotoxicity. Comparison of the cerebellum proteome from 3-month-old unexposed and PCB138-exposed male offspring was performed using state-ofthe-art label-free semiquantitative mass spectrometry method. Biological pathways associated with Ca21 homeostasis and androgen receptor signaling pathways were primarily disrupted. These perturbations may contribute toward a premature ageinglike proteome profile of the cerebellum that is triggered by PCB138 exposure in males. Our proteomic data provide insights into the phenomena that may be contributing to the PCB138 neurotoxicity effects observed in laboratory rodents and correlate with PCB exposure and decreased cognitive functions in humans. As such, this study highlights the importance of PCB138 as a risk factor in developmental neurotoxicity in laboratory rodents and humans.

Original languageEnglish
Pages (from-to)170-179
Number of pages10
JournalToxicological Sciences
Volume123
Issue number1
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Cognitive functions
  • Network analysis.
  • Non-dioxin-like PCBs
  • Proteomics

ASJC Scopus subject areas

  • Toxicology

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    Campagna, R., Brunelli, L., Airoldi, L., Fanelli, R., Hakansson, H., Heimeier, R. A., De Boever, P., Boix, J., Llansola, M., Felipo, V., & Pastorelli, R. (2011). Cerebellum Proteomics addressing the cognitive deficit of rats perinatally exposed to the food-relevant polychlorinated biphenyl 138. Toxicological Sciences, 123(1), 170-179. https://doi.org/10.1093/toxsci/kfr156