Cerebral Autoregulation in Non-Brain Injured Patients: A Systematic Review

Yaroslava Longhitano, Francesca Iannuzzi, Giulia Bonatti, Christian Zanza, Antonio Messina, Daniel Godoy, Wojciech Dabrowski, Li Xiuyun, Marek Czosnyka, Paolo Pelosi, Rafael Badenes, Chiara Robba

Research output: Contribution to journalReview articlepeer-review


Introduction: Cerebral autoregulation (CA) plays a fundamental role in the maintenance of adequate cerebral blood flow (CBF). CA monitoring, through direct and indirect techniques, may guide an appropriate therapeutic approach aimed at improving CBF and reducing neurological complications; so far, the role of CA has been investigated mainly in brain-injured patients. The aim of this study is to investigate the role of CA in non-brain injured patients. Methods: A systematic consultation of literature was carried out. Search terms included: “CA and sepsis,” “CA and surgery,” and “CA and non-brain injury.” Results: Our research individualized 294 studies and after screening, 22 studies were analyzed in this study. Studies were divided in three groups: CA in sepsis and septic shock, CA during surgery, and CA in the pediatric population. Studies in sepsis and intraoperative setting highlighted a relationship between the incidence of sepsis-associated delirium and impaired CA. The most investigated setting in the pediatric population is cardiac surgery, but the role and measurement of CA need to be further elucidated. Conclusion: In non-brain injured patients, impaired CA may result in cognitive dysfunction, neurological damage, worst outcome, and increased mortality. Monitoring CA might be a useful tool for the bedside optimization and individualization of the clinical management in this group of patients.

Original languageEnglish
Article number732176
JournalFrontiers in Neurology
Publication statusPublished - Nov 16 2021


  • cerebral autoregulation
  • neurologic outcome
  • non-brain injury
  • pediatric surgery
  • perioperative care
  • sepsis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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