Cerebral blood flow and metabolism in therapeutic insulin coma

Paolo Della Porta, Anna Teresa Maiolo, Vittor Ugo Negri, Emanuele Rossella

Research output: Contribution to journalArticlepeer-review


The cerebral blood flow, cerebral metabolic rate of oxygen and glucose and R.Q. were studied in 14 subjects suffering from schizophrenia in the active stage, during a cycle of Sakel insulin therapy. The basal conditions, the state of marked hypoglycemia, the deep coma and the return of consciousness after administration of glucose were studied. Starting from basal data within normal limits, a significant increase of cerebral blood flow in coma was particularly observed. Furthermore, while reduction of the cerebral glucose utilization was noted, increasing progressively from the state of marked hypoglycemia at 90′ to coma, the oxygen utilization did not show any considerable variations on the average, although falling in some cases. These results are discussed in relation to the data reported in the literature.

Original languageEnglish
Pages (from-to)131-140
Number of pages10
Issue number2
Publication statusPublished - Feb 1964

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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