Cerebral blood flow in experimental ischemia assessed by19F magnetic resonance spectroscopy in cats

A. Brunetti, G. Nagashima, A. Bizzi, D. J. DesPres, J. R. Alger

Research output: Contribution to journalArticle

Abstract

We evaluated a19F magnetic resonance spectroscopic technique that detects Freon-23 washout as a means of measuring cerebral blood flow in halothane-anesthetized adult cats during and after transient cerebral ischemia produced by vascular occlusion. The experiments were performed to test the ability of this recently developed method to detect postischemic flow deficits. Results were consistent with postischemic hypoperfusion. The method also proved valuable for measuring small residual flow during vascular occlusion. Our experiments indicate that this method provides simple, rapid, and repeatable flow measurements that can augment magnetic resonance examinations of cerebral metabolic parameters in the study of ischemia.

Original languageEnglish
Pages (from-to)1439-1444
Number of pages6
JournalStroke
Volume21
Issue number10
Publication statusPublished - 1990

Keywords

  • Cats
  • Cerebral blood flow
  • Cerebral ischemia
  • Nuclear magnetic resonance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Neuroscience(all)

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    Brunetti, A., Nagashima, G., Bizzi, A., DesPres, D. J., & Alger, J. R. (1990). Cerebral blood flow in experimental ischemia assessed by19F magnetic resonance spectroscopy in cats. Stroke, 21(10), 1439-1444.