Abstract
We used single photon emission tomography to study regional cerebral perfusion in patients with different forms of spinocerebellar degeneration: 6 patients with Friedreich's ataxia (FA), 6 with early-onset cerebellar ataxia with retained tendon reflexes (EOCA), 5 with autosomal dominant cerebellar ataxia type 1 (ADCA I) and 11 with idiopathic late-onset cerebellar ataxia (ILOCA). The results were related to clinical and magnetic resonance imaging (MRI) findings. Cerebellar hypoperfusion was constant in ADCA I and frequent in patients with other spinocerebellar degenerations. Brain stem hypoperfusion was constant in ADCA I, frequent in ILOCA patients with pontocerebellar atrophy and absent in FA and EOCA. FA and EOCA often showed a reduction in the parietotemporal cortex blood flow, which was not related to cortical atrophy. ILOCA patients had an asymmetric pattern in the temporal areas with decreased blood flow in the right side only. Caudate hypoperfusion was found in ADCA I patients. Cerebral atrophy did not account for changes in regional blood flow, which probably indicate early involvement of cerebral structures.
| Original language | English |
|---|---|
| Pages (from-to) | 603-608 |
| Number of pages | 6 |
| Journal | Journal of Neurology |
| Volume | 245 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1998 |
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Keywords
- Cerebral blood flow
- Single photon emission tomography
- Spinocerebellar degeneration
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Cerebral blood flow in spinocerebellar degenerations : A single photon emission tomography study in 28 patients. / De Michele, G.; Mainenti, P. P.; Soricelli, A.; Di Salle, F.; Salvatore, E.; Longobardi, M. R.; Postiglione, A.; Salvatore, M.; Filla, A.
In: Journal of Neurology, Vol. 245, No. 9, 1998, p. 603-608.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebral blood flow in spinocerebellar degenerations
T2 - A single photon emission tomography study in 28 patients
AU - De Michele, G.
AU - Mainenti, P. P.
AU - Soricelli, A.
AU - Di Salle, F.
AU - Salvatore, E.
AU - Longobardi, M. R.
AU - Postiglione, A.
AU - Salvatore, M.
AU - Filla, A.
PY - 1998
Y1 - 1998
N2 - We used single photon emission tomography to study regional cerebral perfusion in patients with different forms of spinocerebellar degeneration: 6 patients with Friedreich's ataxia (FA), 6 with early-onset cerebellar ataxia with retained tendon reflexes (EOCA), 5 with autosomal dominant cerebellar ataxia type 1 (ADCA I) and 11 with idiopathic late-onset cerebellar ataxia (ILOCA). The results were related to clinical and magnetic resonance imaging (MRI) findings. Cerebellar hypoperfusion was constant in ADCA I and frequent in patients with other spinocerebellar degenerations. Brain stem hypoperfusion was constant in ADCA I, frequent in ILOCA patients with pontocerebellar atrophy and absent in FA and EOCA. FA and EOCA often showed a reduction in the parietotemporal cortex blood flow, which was not related to cortical atrophy. ILOCA patients had an asymmetric pattern in the temporal areas with decreased blood flow in the right side only. Caudate hypoperfusion was found in ADCA I patients. Cerebral atrophy did not account for changes in regional blood flow, which probably indicate early involvement of cerebral structures.
AB - We used single photon emission tomography to study regional cerebral perfusion in patients with different forms of spinocerebellar degeneration: 6 patients with Friedreich's ataxia (FA), 6 with early-onset cerebellar ataxia with retained tendon reflexes (EOCA), 5 with autosomal dominant cerebellar ataxia type 1 (ADCA I) and 11 with idiopathic late-onset cerebellar ataxia (ILOCA). The results were related to clinical and magnetic resonance imaging (MRI) findings. Cerebellar hypoperfusion was constant in ADCA I and frequent in patients with other spinocerebellar degenerations. Brain stem hypoperfusion was constant in ADCA I, frequent in ILOCA patients with pontocerebellar atrophy and absent in FA and EOCA. FA and EOCA often showed a reduction in the parietotemporal cortex blood flow, which was not related to cortical atrophy. ILOCA patients had an asymmetric pattern in the temporal areas with decreased blood flow in the right side only. Caudate hypoperfusion was found in ADCA I patients. Cerebral atrophy did not account for changes in regional blood flow, which probably indicate early involvement of cerebral structures.
KW - Cerebral blood flow
KW - Single photon emission tomography
KW - Spinocerebellar degeneration
UR - http://www.scopus.com/inward/record.url?scp=0031693396&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031693396&partnerID=8YFLogxK
U2 - 10.1007/s004150050253
DO - 10.1007/s004150050253
M3 - Article
C2 - 9758299
AN - SCOPUS:0031693396
VL - 245
SP - 603
EP - 608
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 9
ER -