Cerebral blood flow studies in the diagnosis and management of intrauterine growth restriction

Edgar Hernandez-Andrade, Tamara Stampalija, Francesc Figueras

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose of Review: To provide evidence that fetal brain vasodilatation can be related with postnatal cerebral structural and functional complications. Recent Findings: Most early-onset intrauterine growth restricted (IUGR) fetuses show signs of brain vasodilatation. As most of them are born prematurely, a high prevalence of short-term and long-term neurological complications is expected. However, the clinical significance of brain vasodilatation might be different. In the early stage of fetal deterioration, the risk of structural brain damage is low, but at advanced stages there is an increased risk of periventricular leukomalacia and intraventricular hemorrhage. The presence of brain vasodilatation in fetuses with an estimated fetal weight below the 10th centile but normal umbilical artery Doppler can be used to identify late-onset IUGR fetuses with latent placental insufficiency. These fetuses have an increased risk of abnormal neurological performance at birth and at 2 years of age. Summary: Changes in cerebral brain blood perfusion in IUGR fetuses can be detected by Doppler ultrasound techniques. Despite its association with structural and functional neurological damage after birth, fetal brain vasodilatation is usually not considered in the decision to deliver, with the only exception of the 'return' to normal middle cerebral artery pulsatility index, which is highly associated with an increased risk for perinatal mortality.

Original languageEnglish
Pages (from-to)138-144
Number of pages7
JournalCurrent Opinion in Obstetrics and Gynecology
Volume25
Issue number2
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Cerebrovascular Circulation
Prenatal Diagnosis
Vasodilation
Fetus
Brain
Growth
Parturition
Placental Insufficiency
Periventricular Leukomalacia
Doppler Ultrasonography
Fetal Weight
Umbilical Arteries
Perinatal Mortality
Middle Cerebral Artery
Perfusion
Hemorrhage

Keywords

  • Doppler
  • fetal brain vasodilatation
  • intrauterine growth restriction
  • neurological outcome

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Cerebral blood flow studies in the diagnosis and management of intrauterine growth restriction. / Hernandez-Andrade, Edgar; Stampalija, Tamara; Figueras, Francesc.

In: Current Opinion in Obstetrics and Gynecology, Vol. 25, No. 2, 04.2013, p. 138-144.

Research output: Contribution to journalArticle

@article{c582bce8a7504de6881458c4ad0fbcb4,
title = "Cerebral blood flow studies in the diagnosis and management of intrauterine growth restriction",
abstract = "Purpose of Review: To provide evidence that fetal brain vasodilatation can be related with postnatal cerebral structural and functional complications. Recent Findings: Most early-onset intrauterine growth restricted (IUGR) fetuses show signs of brain vasodilatation. As most of them are born prematurely, a high prevalence of short-term and long-term neurological complications is expected. However, the clinical significance of brain vasodilatation might be different. In the early stage of fetal deterioration, the risk of structural brain damage is low, but at advanced stages there is an increased risk of periventricular leukomalacia and intraventricular hemorrhage. The presence of brain vasodilatation in fetuses with an estimated fetal weight below the 10th centile but normal umbilical artery Doppler can be used to identify late-onset IUGR fetuses with latent placental insufficiency. These fetuses have an increased risk of abnormal neurological performance at birth and at 2 years of age. Summary: Changes in cerebral brain blood perfusion in IUGR fetuses can be detected by Doppler ultrasound techniques. Despite its association with structural and functional neurological damage after birth, fetal brain vasodilatation is usually not considered in the decision to deliver, with the only exception of the 'return' to normal middle cerebral artery pulsatility index, which is highly associated with an increased risk for perinatal mortality.",
keywords = "Doppler, fetal brain vasodilatation, intrauterine growth restriction, neurological outcome",
author = "Edgar Hernandez-Andrade and Tamara Stampalija and Francesc Figueras",
year = "2013",
month = "4",
doi = "10.1097/GCO.0b013e32835e0e9c",
language = "English",
volume = "25",
pages = "138--144",
journal = "Current Opinion in Obstetrics and Gynecology",
issn = "1040-872X",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Cerebral blood flow studies in the diagnosis and management of intrauterine growth restriction

AU - Hernandez-Andrade, Edgar

AU - Stampalija, Tamara

AU - Figueras, Francesc

PY - 2013/4

Y1 - 2013/4

N2 - Purpose of Review: To provide evidence that fetal brain vasodilatation can be related with postnatal cerebral structural and functional complications. Recent Findings: Most early-onset intrauterine growth restricted (IUGR) fetuses show signs of brain vasodilatation. As most of them are born prematurely, a high prevalence of short-term and long-term neurological complications is expected. However, the clinical significance of brain vasodilatation might be different. In the early stage of fetal deterioration, the risk of structural brain damage is low, but at advanced stages there is an increased risk of periventricular leukomalacia and intraventricular hemorrhage. The presence of brain vasodilatation in fetuses with an estimated fetal weight below the 10th centile but normal umbilical artery Doppler can be used to identify late-onset IUGR fetuses with latent placental insufficiency. These fetuses have an increased risk of abnormal neurological performance at birth and at 2 years of age. Summary: Changes in cerebral brain blood perfusion in IUGR fetuses can be detected by Doppler ultrasound techniques. Despite its association with structural and functional neurological damage after birth, fetal brain vasodilatation is usually not considered in the decision to deliver, with the only exception of the 'return' to normal middle cerebral artery pulsatility index, which is highly associated with an increased risk for perinatal mortality.

AB - Purpose of Review: To provide evidence that fetal brain vasodilatation can be related with postnatal cerebral structural and functional complications. Recent Findings: Most early-onset intrauterine growth restricted (IUGR) fetuses show signs of brain vasodilatation. As most of them are born prematurely, a high prevalence of short-term and long-term neurological complications is expected. However, the clinical significance of brain vasodilatation might be different. In the early stage of fetal deterioration, the risk of structural brain damage is low, but at advanced stages there is an increased risk of periventricular leukomalacia and intraventricular hemorrhage. The presence of brain vasodilatation in fetuses with an estimated fetal weight below the 10th centile but normal umbilical artery Doppler can be used to identify late-onset IUGR fetuses with latent placental insufficiency. These fetuses have an increased risk of abnormal neurological performance at birth and at 2 years of age. Summary: Changes in cerebral brain blood perfusion in IUGR fetuses can be detected by Doppler ultrasound techniques. Despite its association with structural and functional neurological damage after birth, fetal brain vasodilatation is usually not considered in the decision to deliver, with the only exception of the 'return' to normal middle cerebral artery pulsatility index, which is highly associated with an increased risk for perinatal mortality.

KW - Doppler

KW - fetal brain vasodilatation

KW - intrauterine growth restriction

KW - neurological outcome

UR - http://www.scopus.com/inward/record.url?scp=84874947645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874947645&partnerID=8YFLogxK

U2 - 10.1097/GCO.0b013e32835e0e9c

DO - 10.1097/GCO.0b013e32835e0e9c

M3 - Article

VL - 25

SP - 138

EP - 144

JO - Current Opinion in Obstetrics and Gynecology

JF - Current Opinion in Obstetrics and Gynecology

SN - 1040-872X

IS - 2

ER -