Cerebral calcifications and celiac disease. A review of the literature

Celiac Disease or gluten-sensitive enteropathy is a common disorders, especially in European countries. In genetically susceptible patients, ingestion of the cereal proteins trigger an immunomediated damage of the small bowel mucosa.Textbook of Neurology and Internal Medicine, and recently published paper (Michalski 1994) underlie the variable clinical presentation, relatied to malabsoption.Careful revision of the Literature indicate a peculiar association between celiac disease and cerebral calcification: from 1988 several series of cases have been described. The pathogenetic relationship is not known, in particlar folic deficiency and immunomediated vascular damage, silica tossicity have been considered.We report our experience of 1 case and perform a review of the Literature, discussing the differentclinico-radiological presentation.