Abstract
Clinical presentation and response to treatment in 20 patients with cerebral cavernous angiomas (ACC) are reported. In 30% ACC were multiple with 3 familiar cases. The most frequent manifestation at onset were epileptic seizures; all familial cases presented multiple ACC and molecular analysis revealed a nucleotidic substitution CAA→TAA in the Krit1 gene. Ten cases underwent a surgical approach with lesionectomy; an intraoperative elettrocorticography (Echo) was performed in 5 cases. Neurosurgery has been associated with a good control of seizures (Engel Class I, II) in 80% of cases, while only 44% had a good outcome between non surgical cases. A good prognosis was associated with a short history of epilepsy, single ACC and good concordance between electroclinical data and the site of the lesion.
Translated title of the contribution | Cerebral cavernous angiomas and epilepsy: Clinical features and therapy in 20 cases |
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Original language | Italian |
Pages (from-to) | 125-127 |
Number of pages | 3 |
Journal | Bollettino - Lega Italiana contro l'Epilessia |
Issue number | 133-134 |
Publication status | Published - Jul 2006 |
ASJC Scopus subject areas
- Clinical Neurology