Angiomi cavernosi cerebrali ed epilessia: Rilievi clinici e trattamento in 20 casi

P. Banfi; E. Guaschino; M. L. Delodovici; S. Peron; G. Tomei; G. Bono

Angiomi cavernosi cerebrali ed epilessia: Rilievi clinici e trattamento in 20 casi

Translated title of the contribution: Cerebral cavernous angiomas and epilepsy: Clinical features and therapy in 20 cases

P. Banfi, E. Guaschino, M. L. Delodovici, S. Peron, G. Tomei, G. Bono

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

Clinical presentation and response to treatment in 20 patients with cerebral cavernous angiomas (ACC) are reported. In 30% ACC were multiple with 3 familiar cases. The most frequent manifestation at onset were epileptic seizures; all familial cases presented multiple ACC and molecular analysis revealed a nucleotidic substitution CAA→TAA in the Krit1 gene. Ten cases underwent a surgical approach with lesionectomy; an intraoperative elettrocorticography (Echo) was performed in 5 cases. Neurosurgery has been associated with a good control of seizures (Engel Class I, II) in 80% of cases, while only 44% had a good outcome between non surgical cases. A good prognosis was associated with a short history of epilepsy, single ACC and good concordance between electroclinical data and the site of the lesion.

Translated title of the contribution	Cerebral cavernous angiomas and epilepsy: Clinical features and therapy in 20 cases
Original language	Italian
Pages (from-to)	125-127
Number of pages	3
Journal	Bollettino - Lega Italiana contro l'Epilessia
Issue number	133-134
Publication status	Published - Jul 2006

ASJC Scopus subject areas

Clinical Neurology

Cite this

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title = "Angiomi cavernosi cerebrali ed epilessia: Rilievi clinici e trattamento in 20 casi",

abstract = "Clinical presentation and response to treatment in 20 patients with cerebral cavernous angiomas (ACC) are reported. In 30% ACC were multiple with 3 familiar cases. The most frequent manifestation at onset were epileptic seizures; all familial cases presented multiple ACC and molecular analysis revealed a nucleotidic substitution CAA→TAA in the Krit1 gene. Ten cases underwent a surgical approach with lesionectomy; an intraoperative elettrocorticography (Echo) was performed in 5 cases. Neurosurgery has been associated with a good control of seizures (Engel Class I, II) in 80% of cases, while only 44% had a good outcome between non surgical cases. A good prognosis was associated with a short history of epilepsy, single ACC and good concordance between electroclinical data and the site of the lesion.",

keywords = "Cavernous angiomas, Epilepsy, Lesionectomy",

author = "P. Banfi and E. Guaschino and Delodovici, {M. L.} and S. Peron and G. Tomei and G. Bono",

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T1 - Angiomi cavernosi cerebrali ed epilessia

T2 - Rilievi clinici e trattamento in 20 casi

AU - Banfi, P.

AU - Guaschino, E.

AU - Delodovici, M. L.

AU - Peron, S.

AU - Tomei, G.

AU - Bono, G.

PY - 2006/7

Y1 - 2006/7

N2 - Clinical presentation and response to treatment in 20 patients with cerebral cavernous angiomas (ACC) are reported. In 30% ACC were multiple with 3 familiar cases. The most frequent manifestation at onset were epileptic seizures; all familial cases presented multiple ACC and molecular analysis revealed a nucleotidic substitution CAA→TAA in the Krit1 gene. Ten cases underwent a surgical approach with lesionectomy; an intraoperative elettrocorticography (Echo) was performed in 5 cases. Neurosurgery has been associated with a good control of seizures (Engel Class I, II) in 80% of cases, while only 44% had a good outcome between non surgical cases. A good prognosis was associated with a short history of epilepsy, single ACC and good concordance between electroclinical data and the site of the lesion.

AB - Clinical presentation and response to treatment in 20 patients with cerebral cavernous angiomas (ACC) are reported. In 30% ACC were multiple with 3 familiar cases. The most frequent manifestation at onset were epileptic seizures; all familial cases presented multiple ACC and molecular analysis revealed a nucleotidic substitution CAA→TAA in the Krit1 gene. Ten cases underwent a surgical approach with lesionectomy; an intraoperative elettrocorticography (Echo) was performed in 5 cases. Neurosurgery has been associated with a good control of seizures (Engel Class I, II) in 80% of cases, while only 44% had a good outcome between non surgical cases. A good prognosis was associated with a short history of epilepsy, single ACC and good concordance between electroclinical data and the site of the lesion.

KW - Cavernous angiomas

KW - Epilepsy

KW - Lesionectomy

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Angiomi cavernosi cerebrali ed epilessia: Rilievi clinici e trattamento in 20 casi

Abstract

ASJC Scopus subject areas

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