Angiomi cavernosi cerebrali ed epilessia: Rilievi clinici e trattamento in 20 casi

Translated title of the contribution: Cerebral cavernous angiomas and epilepsy: Clinical features and therapy in 20 cases

P. Banfi, E. Guaschino, M. L. Delodovici, S. Peron, G. Tomei, G. Bono

Research output: Contribution to journalArticle

Abstract

Clinical presentation and response to treatment in 20 patients with cerebral cavernous angiomas (ACC) are reported. In 30% ACC were multiple with 3 familiar cases. The most frequent manifestation at onset were epileptic seizures; all familial cases presented multiple ACC and molecular analysis revealed a nucleotidic substitution CAA→TAA in the Krit1 gene. Ten cases underwent a surgical approach with lesionectomy; an intraoperative elettrocorticography (Echo) was performed in 5 cases. Neurosurgery has been associated with a good control of seizures (Engel Class I, II) in 80% of cases, while only 44% had a good outcome between non surgical cases. A good prognosis was associated with a short history of epilepsy, single ACC and good concordance between electroclinical data and the site of the lesion.

Translated title of the contributionCerebral cavernous angiomas and epilepsy: Clinical features and therapy in 20 cases
Original languageItalian
Pages (from-to)125-127
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number133-134
Publication statusPublished - Jul 2006

ASJC Scopus subject areas

  • Clinical Neurology

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    Banfi, P., Guaschino, E., Delodovici, M. L., Peron, S., Tomei, G., & Bono, G. (2006). Angiomi cavernosi cerebrali ed epilessia: Rilievi clinici e trattamento in 20 casi. Bollettino - Lega Italiana contro l'Epilessia, (133-134), 125-127.