Abstract
Clinical presentation and response to treatment in 20 patients with cerebral cavernous angiomas (ACC) are reported. In 30% ACC were multiple with 3 familiar cases. The most frequent manifestation at onset were epileptic seizures; all familial cases presented multiple ACC and molecular analysis revealed a nucleotidic substitution CAA→TAA in the Krit1 gene. Ten cases underwent a surgical approach with lesionectomy; an intraoperative elettrocorticography (Echo) was performed in 5 cases. Neurosurgery has been associated with a good control of seizures (Engel Class I, II) in 80% of cases, while only 44% had a good outcome between non surgical cases. A good prognosis was associated with a short history of epilepsy, single ACC and good concordance between electroclinical data and the site of the lesion.
| Original language | Italian |
|---|---|
| Pages (from-to) | 125-127 |
| Number of pages | 3 |
| Journal | Bollettino - Lega Italiana contro l'Epilessia |
| Issue number | 133-134 |
| Publication status | Published - Jul 2006 |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Angiomi cavernosi cerebrali ed epilessia : Rilievi clinici e trattamento in 20 casi. / Banfi, P.; Guaschino, E.; Delodovici, M. L.; Peron, S.; Tomei, G.; Bono, G.
In: Bollettino - Lega Italiana contro l'Epilessia, No. 133-134, 07.2006, p. 125-127.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Angiomi cavernosi cerebrali ed epilessia
T2 - Rilievi clinici e trattamento in 20 casi
AU - Banfi, P.
AU - Guaschino, E.
AU - Delodovici, M. L.
AU - Peron, S.
AU - Tomei, G.
AU - Bono, G.
PY - 2006/7
Y1 - 2006/7
N2 - Clinical presentation and response to treatment in 20 patients with cerebral cavernous angiomas (ACC) are reported. In 30% ACC were multiple with 3 familiar cases. The most frequent manifestation at onset were epileptic seizures; all familial cases presented multiple ACC and molecular analysis revealed a nucleotidic substitution CAA→TAA in the Krit1 gene. Ten cases underwent a surgical approach with lesionectomy; an intraoperative elettrocorticography (Echo) was performed in 5 cases. Neurosurgery has been associated with a good control of seizures (Engel Class I, II) in 80% of cases, while only 44% had a good outcome between non surgical cases. A good prognosis was associated with a short history of epilepsy, single ACC and good concordance between electroclinical data and the site of the lesion.
AB - Clinical presentation and response to treatment in 20 patients with cerebral cavernous angiomas (ACC) are reported. In 30% ACC were multiple with 3 familiar cases. The most frequent manifestation at onset were epileptic seizures; all familial cases presented multiple ACC and molecular analysis revealed a nucleotidic substitution CAA→TAA in the Krit1 gene. Ten cases underwent a surgical approach with lesionectomy; an intraoperative elettrocorticography (Echo) was performed in 5 cases. Neurosurgery has been associated with a good control of seizures (Engel Class I, II) in 80% of cases, while only 44% had a good outcome between non surgical cases. A good prognosis was associated with a short history of epilepsy, single ACC and good concordance between electroclinical data and the site of the lesion.
KW - Cavernous angiomas
KW - Epilepsy
KW - Lesionectomy
UR - http://www.scopus.com/inward/record.url?scp=33847681518&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847681518&partnerID=8YFLogxK
M3 - Articolo
SP - 125
EP - 127
JO - Bollettino - Lega Italiana contro l'Epilessia
JF - Bollettino - Lega Italiana contro l'Epilessia
SN - 0394-560X
IS - 133-134
ER -