TY - JOUR
T1 - Cerebral extracellular preamyloid deposits in Alzheimer's disease, Down syndrome and nondemented elderly individuals.
AU - Tagliavini, F.
AU - Giaccone, G.
AU - Linoli, G.
AU - Frangione, B.
AU - Bugiani, O.
PY - 1989
Y1 - 1989
N2 - Using anti-SP28 (a polyclonal antibody to a 28 residue synthetic peptide homologous to the NH2-terminal region of Alzheimer amyloid beta-protein) to investigate the cerebral cortex of 8 Alzheimer and 6 Down patients and 13 nondemented individuals, we found that, besides senile plaques and congophilic vessels, extracellular deposits unrelated to degenerating neurites, tangle-bearing neurons or congophilic vessels were labelled. These deposits were observed in all Alzheimer and 4 Down patients, and in 5 nondemented individuals. The material accumulated in these deposits did not react with Congo red, thioflavine S or, on some occasions, silver salts and therefore might have been constituted by beta-protein and/or beta-protein precursors lacking the conformation of amyloid fibrils.
AB - Using anti-SP28 (a polyclonal antibody to a 28 residue synthetic peptide homologous to the NH2-terminal region of Alzheimer amyloid beta-protein) to investigate the cerebral cortex of 8 Alzheimer and 6 Down patients and 13 nondemented individuals, we found that, besides senile plaques and congophilic vessels, extracellular deposits unrelated to degenerating neurites, tangle-bearing neurons or congophilic vessels were labelled. These deposits were observed in all Alzheimer and 4 Down patients, and in 5 nondemented individuals. The material accumulated in these deposits did not react with Congo red, thioflavine S or, on some occasions, silver salts and therefore might have been constituted by beta-protein and/or beta-protein precursors lacking the conformation of amyloid fibrils.
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M3 - Article
C2 - 2532368
AN - SCOPUS:0024846010
VL - 317
SP - 1001
EP - 1005
JO - Progress in Clinical and Biological Research
JF - Progress in Clinical and Biological Research
SN - 0361-7742
ER -