Cerebral glucose metabolism in neurofibromatosis type 1 assessed with [18F]-2-fluoro-2-deoxy-D-glucose and PET

P. Balestri, G. Lucignani, A. Fois, L. Magliani, L. Calistri, C. Grana, R. M. Di Bartolo, D. Perani, F. Fazio

Research output: Contribution to journalArticlepeer-review


Cerebral PET with [18FJ-2-fluoro-2-deoxy-D-glucose has been performed in four patients with neurofibromatosis type 1 (NF1) to assess the relation between cerebral metabolic activity, MRI, and the presence of neurological symptoms, including seizures, as well as mental and language retardation. Widespread hypometabolism occurred in three of the patients. The lesions on MRI, which were localised in the subcortical white matter and grey structures, had normal rates of glucose metabolism. This finding suggests that the abnormalities seen on MRI are not due to defective blood supply, localised oedema, or grey matter heterotopic foci as previously hypothesised. The presence of the hypometabolic areas seems to be inconsistently related to the occurrence of seizures and is not proportional to the degree of mental impairment. This study provides evidence of a widespread cerebral hypometabolism that is not related to the presence ofMRI abnormalities; conversely normal metabolism was present in the areas with an abnormal 1RI signal.

Original languageEnglish
Pages (from-to)1479-1483
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number12
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology


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