Cerebral glucose metabolism in patients with spasmodic torticollis

Stefanie Magyar-Lehmann, Angelo Antonini, Ulrich Roelcke, Ralph P. Maguire, John Missimer, Manuel Meyer, K. L. Leenders

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The pathophysiology of spasmodic torticollis is not clear. Basal ganglia dysfunction has been suggested to underlie this clinical syndrome. We studied resting cerebral glucose metabolism in 10 spasmodic torticollis patients and 10 healthy controls by using positron-emission tomography and [18F]2-fluoro-2-deoxy-D-glucose. Statistical parametric mapping (SPM95) was used to compare both groups on a pixel-by-pixel basis. Torticollis patients showed a significantly higher glucose metabolism bilaterally in the lentiform nucleus (p <0.005). Analyses performed using normalization of regional to global glucose metabolism confirmed this finding (controls, 1.26 ± 0.06, and patients, 1.35 ± 0.06; p <0.01). The torticollis score did not correlate with glucose metabolism, nor did disease duration or side of chin direction. Our results indicate that the lentiform nucleus plays a predominant role in the pathophysiology of idiopathic spasmodic torticollis.

Original languageEnglish
Pages (from-to)704-708
Number of pages5
JournalMovement Disorders
Volume12
Issue number5
DOIs
Publication statusPublished - 1997

Fingerprint

Torticollis
Glucose
Corpus Striatum
Chin
Fluorodeoxyglucose F18
Basal Ganglia
Positron-Emission Tomography

Keywords

  • [F]2-fluoro-2-deoxy-D-glucose
  • Glucose metabolism
  • Lentiform nucleus
  • Positron-emission tomography
  • Spasmodic torticollis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Magyar-Lehmann, S., Antonini, A., Roelcke, U., Maguire, R. P., Missimer, J., Meyer, M., & Leenders, K. L. (1997). Cerebral glucose metabolism in patients with spasmodic torticollis. Movement Disorders, 12(5), 704-708. https://doi.org/10.1002/mds.870120513

Cerebral glucose metabolism in patients with spasmodic torticollis. / Magyar-Lehmann, Stefanie; Antonini, Angelo; Roelcke, Ulrich; Maguire, Ralph P.; Missimer, John; Meyer, Manuel; Leenders, K. L.

In: Movement Disorders, Vol. 12, No. 5, 1997, p. 704-708.

Research output: Contribution to journalArticle

Magyar-Lehmann, S, Antonini, A, Roelcke, U, Maguire, RP, Missimer, J, Meyer, M & Leenders, KL 1997, 'Cerebral glucose metabolism in patients with spasmodic torticollis', Movement Disorders, vol. 12, no. 5, pp. 704-708. https://doi.org/10.1002/mds.870120513
Magyar-Lehmann S, Antonini A, Roelcke U, Maguire RP, Missimer J, Meyer M et al. Cerebral glucose metabolism in patients with spasmodic torticollis. Movement Disorders. 1997;12(5):704-708. https://doi.org/10.1002/mds.870120513
Magyar-Lehmann, Stefanie ; Antonini, Angelo ; Roelcke, Ulrich ; Maguire, Ralph P. ; Missimer, John ; Meyer, Manuel ; Leenders, K. L. / Cerebral glucose metabolism in patients with spasmodic torticollis. In: Movement Disorders. 1997 ; Vol. 12, No. 5. pp. 704-708.
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