Cerebral grey matter pathology and fatigue in patients with multiple sclerosis: A preliminary study

Research output: Contribution to journalArticlepeer-review

Abstract

In patients with multiple sclerosis (MS), we investigated whether the extent of cerebral grey matter (GM) pathology is associated with the presence and severity of fatigue. We quantified cerebral GM pathology in 28 MS patients (14 with fatigue and 14 without fatigue) using magnetization transfer (MT) and diffusion tensor (DT) magnetic resonance imaging (MRI). The average MT ratio and mean diffusivity from cerebral GM did not differ between fatigued and non-fatigued patients. Fatigued and non-fatigued patients also did not differ in terms of GM pathology of the cerebral cortex of the frontal lobe and basal ganglia. No correlations were found between the fatigue severity scale scores and any of the MT- and DT-MRI quantities. These preliminary results suggest that structural GM pathology is not a major contributing factor to the development of fatigue in patients with MS.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalJournal of the Neurological Sciences
Volume194
Issue number1
DOIs
Publication statusPublished - Feb 15 2002

Keywords

  • Diffusion tensor imaging
  • Fatigue
  • Grey matter
  • Magnetic resonance imaging
  • Magnetization transfer imaging
  • Multiple sclerosis

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Cerebral grey matter pathology and fatigue in patients with multiple sclerosis: A preliminary study'. Together they form a unique fingerprint.

Cite this