Cerebral involvement in stargardt’s disease: A VBM and TBSS study

Gaia Olivo, Paolo Melillo, Sirio Cocozza, Francesco Maria D’Alterio, Anna Prinster, Francesco Testa, Arturo Brunetti, Francesca Simonelli, Mario Quarantelli

Research output: Contribution to journalArticle

Abstract

Purpose: To assess whether and to what extent macro- and/or microstructural modifications are present in the brain of patients with selective central visual loss due to a juvenile macular degeneration, Stargardt’s disease (STGD), taking advantage of the complementary information provided by voxel-based morphometry (VBM) and diffusion tensor imaging (DTI). Methods: Eighteen patients with clinical and molecular diagnosis of STGD related to ABCA4 mutations and 23 normally sighted volunteers of comparable age and sex were enrolled. Structural T1-weighted (T1w) volumes, for brain tissue volume assessment by segmentation, and DTI, for the investigation of diffusivity parameters via a tract-based spatial statistics (TBSS) procedure, were acquired at 3 Tesla in all subjects. All patients underwent a complete ophthalmologic examination, including best-corrected visual acuity (BCVA), biomicroscopy, ophthalmoscopy, electroretinography (ERG), microperimetry, and optical coherence tomography (OCT). Correlations between imaging data and clinical measures were tested. Results: Stargardt’s disease patients showed a significant gray matter (GM) loss bilaterally in the occipital cortices, extending into the right precuneus, and in the fronto-orbital cortices. At TBSS, significant reductions in fractional anisotropy were detected throughout large regions in the supratentorial white matter (WM), more pronounced in the posterior areas. Gray matter volume correlated directly with mean visual sensitivity in the right middle frontal and left calcarine gyri, and inversely with retinal thickness in the left supramarginal gyrus. Conclusions: In STGD, widespread microstructural WM alterations are present, suggestive of minor fiber loss coupled with GM loss, also in cortical regions not traditionally linked to visual pathways, at least partly related to the retinal damage.

Original languageEnglish
Pages (from-to)7388-7397
Number of pages10
JournalInvestigative Ophthalmology and Visual Science
Volume56
Issue number12
DOIs
Publication statusPublished - 2015

Keywords

  • Brain atrophy
  • Diffusion tensor
  • MRI
  • Stargardt’s disease

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Olivo, G., Melillo, P., Cocozza, S., D’Alterio, F. M., Prinster, A., Testa, F., Brunetti, A., Simonelli, F., & Quarantelli, M. (2015). Cerebral involvement in stargardt’s disease: A VBM and TBSS study. Investigative Ophthalmology and Visual Science, 56(12), 7388-7397. https://doi.org/10.1167/iovs.15-16899