Cerebral oxygenation and haemodynamic effects induced by nimodipine in healthy subjects

Daniela Canova, Silvestro Roatta, Giuseppe Micieli, Daniele Bosone

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The cerebrovascular effects of nimodipine are still poorly understood even in the healthy condition; in particular, its effects on tissue oxygenation have never been investigated. The aim of the present study was to investigate changes in cerebral oxygenation and blood volume upon oral administration of nimodipine (90 mg) in the healthy condition. In eight subjects, changes in cerebral tissue oxygenation and blood volume were determined simultaneously with changes in blood velocity of the middle cerebral artery (VMCA) by using, respectively, near infrared spectroscopy (NIRS) and transcranial Doppler ultrasonography (TCD). The subjects also underwent non-invasive assessment of arterial blood pressure (ABP) and endtidal CO2. TCD and NIRS CO2 reactivity indices were also extracted. Nimodipine significantly reduced ABP (11±13%) and increased heart rate, as well as NIRS oxygenation (6.0±4.8%) and blood volume indices (9.4±10.1%), while VMCA was not significantly decreased (2.0±3.5%). Nimodipine slightly but significantly reduced the VMCA response to changes in pCO2 whereas the CO2 reactivity of NIRS parameters was improved. The observed changes in cerebral tissue oxygenation and blood volume indicate nimodipine-induced cerebrovascular dilation and increased perfusion, while the effect on VMCA possibly results from dilation of the insonated artery. The present results cast doubt on the putative nimodipine-induced impairment of CO2 reactivity.

Original languageEnglish
Pages (from-to)169-176
Number of pages8
JournalFunctional Neurology
Volume27
Issue number3
Publication statusPublished - Jul 2012

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Nimodipine
Healthy Volunteers
Near-Infrared Spectroscopy
Hemodynamics
Middle Cerebral Artery
Blood Volume
Doppler Transcranial Ultrasonography
Dilatation
Arterial Pressure
Oral Administration
Arteries
Perfusion
Heart Rate

Keywords

  • Cerebral blood flow
  • Hyperventilation
  • Near infrared spectroscopy
  • Nimodipine
  • Rebreathing

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Cerebral oxygenation and haemodynamic effects induced by nimodipine in healthy subjects. / Canova, Daniela; Roatta, Silvestro; Micieli, Giuseppe; Bosone, Daniele.

In: Functional Neurology, Vol. 27, No. 3, 07.2012, p. 169-176.

Research output: Contribution to journalArticle

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