Ossigenazione cerebrale e spettrofotometria a raggi vicino all'infrarosso

Translated title of the contribution: Cerebral oxygenation and near infrared spectroscopy

Fabio Mosca, Mario Barbarini, Mariarosa Colnaghi, Monica Fumagalli, Milena Bray, Luigi Gagliardi, Lorenza Pugni

Research output: Contribution to journalArticlepeer-review


Near infrared spectroscopy (NIRS) is a new technique which allows non invasive bedside monitoring of cerebral oxygenation and hemodynamics by measuring relative changes in cerebral oxy- and deoxyhaemoglobin and cytochrome aa3. We have applied this technique to evaluate the possible effects on cerebral oxygenation and hemodyamics of clinical procedures usually performed on preterm infants: • endotracheal suctioning, and we have demonstrated that the magnitude and the duration of the negative effects of open system are significantly reduced using closed endotracheal suctioning system; • withdrawal and infusion through umbilical vein and artery cause significant changes in cerebral hemodynamics: these effects are significantly reduced after administration of ibuprofen; • treatment of patent ductus arteriosus with ibuprofen does not significantly reduce cerebral perfusion and oxygen availability compared to indomethacin and ibuprofen administration also does not affect cerebral vasoreactivity to arterial carbon dioxide tension; • administration of different types and doses of natural surfactant causes different changes in cerebral hemodynamics and these effects seem to be dose-related. Therefore NIRS is an useful device to investigate cerebral oxygenation state of preterm infants and new possibilities could derive from the introduction of a new NIRS method which allows to measure the tissue oxygenation index.

Translated title of the contributionCerebral oxygenation and near infrared spectroscopy
Original languageItalian
Pages (from-to)599-607
Number of pages9
JournalActa Biomedica
Issue numberSUPPL. 1
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Medicine(all)


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