Cerebral Oxygenation, Superior Vena Cava Flow, Severe Intraventricular Hemorrhage and Mortality in 60 Very Low Birth Weight Infants

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Abstract

Background: Brain vulnerability in the critically ill preterm newborn may be related to the burden of cerebral hypoxygenation and hypoperfusion during the immediate postnatal period. Objective: We determined the association between adverse outcomes [death or high grade intraventricular hemorrhage (IVH)] and continuous cerebral tissue oxygen saturation (rSO2), superior vena cava flow (SVCf) and cerebral fractional oxygen extraction (CFOE) in very low birth weight (VLBW) infants during the first 48 h of life. Methods: We studied a prospective cohort of 60 VLBW infants admitted to our neonatal intensive care unit within the first 6 h of life between March 2010 and June 2012. rSO2 (expressed as a number of summary measures) was continuously monitored with near-infrared spectroscopy (INVOS 5100 Somanetic) during the first 48 h of life, SCVf was measured at 4-6, 12, 24 and 48 h after birth, and CFOE was calculated. Results: The mean gestational age was 27.9 (SD 2.39); 8 infants died (13.3%) and 7 developed IVH grade III-IV: 1 in the alive group and 6 in the deceased group (p <0.001). The odds ratio for death was 1.08 (95% CI: 1.015-1.15, p = 0.016) for each 10 periods of rSO2 values 2 ≤40% and SVCf

Original languageEnglish
Pages (from-to)246-252
Number of pages7
JournalNeonatology
Volume108
Issue number4
DOIs
Publication statusPublished - Oct 30 2015

Fingerprint

Very Low Birth Weight Infant
Superior Vena Cava
Hemorrhage
Oxygen
Mortality
Near-Infrared Spectroscopy
Neonatal Intensive Care Units
Cerebral Hemorrhage
Critical Illness
Gestational Age
Odds Ratio
Parturition
Newborn Infant
Brain

Keywords

  • Cerebral fractional oxygen extraction
  • Mortality
  • Near-infrared spectroscopy
  • Superior vena cava
  • Very low birth weight infants

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

@article{877cdc420e3a43dd8d8d9f5a6707bb7b,
title = "Cerebral Oxygenation, Superior Vena Cava Flow, Severe Intraventricular Hemorrhage and Mortality in 60 Very Low Birth Weight Infants",
abstract = "Background: Brain vulnerability in the critically ill preterm newborn may be related to the burden of cerebral hypoxygenation and hypoperfusion during the immediate postnatal period. Objective: We determined the association between adverse outcomes [death or high grade intraventricular hemorrhage (IVH)] and continuous cerebral tissue oxygen saturation (rSO2), superior vena cava flow (SVCf) and cerebral fractional oxygen extraction (CFOE) in very low birth weight (VLBW) infants during the first 48 h of life. Methods: We studied a prospective cohort of 60 VLBW infants admitted to our neonatal intensive care unit within the first 6 h of life between March 2010 and June 2012. rSO2 (expressed as a number of summary measures) was continuously monitored with near-infrared spectroscopy (INVOS 5100 Somanetic) during the first 48 h of life, SCVf was measured at 4-6, 12, 24 and 48 h after birth, and CFOE was calculated. Results: The mean gestational age was 27.9 (SD 2.39); 8 infants died (13.3{\%}) and 7 developed IVH grade III-IV: 1 in the alive group and 6 in the deceased group (p <0.001). The odds ratio for death was 1.08 (95{\%} CI: 1.015-1.15, p = 0.016) for each 10 periods of rSO2 values 2 ≤40{\%} and SVCf",
keywords = "Cerebral fractional oxygen extraction, Mortality, Near-infrared spectroscopy, Superior vena cava, Very low birth weight infants",
author = "Cerbo, {Rosa Maria} and Luigia Scudeller and Roberta Maragliano and Rita Cabano and Margherita Pozzi and Carmine Tinelli and Lina Bollani and Mauro Stronati",
year = "2015",
month = "10",
day = "30",
doi = "10.1159/000438452",
language = "English",
volume = "108",
pages = "246--252",
journal = "Neonatology",
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}

TY - JOUR

T1 - Cerebral Oxygenation, Superior Vena Cava Flow, Severe Intraventricular Hemorrhage and Mortality in 60 Very Low Birth Weight Infants

AU - Cerbo, Rosa Maria

AU - Scudeller, Luigia

AU - Maragliano, Roberta

AU - Cabano, Rita

AU - Pozzi, Margherita

AU - Tinelli, Carmine

AU - Bollani, Lina

AU - Stronati, Mauro

PY - 2015/10/30

Y1 - 2015/10/30

N2 - Background: Brain vulnerability in the critically ill preterm newborn may be related to the burden of cerebral hypoxygenation and hypoperfusion during the immediate postnatal period. Objective: We determined the association between adverse outcomes [death or high grade intraventricular hemorrhage (IVH)] and continuous cerebral tissue oxygen saturation (rSO2), superior vena cava flow (SVCf) and cerebral fractional oxygen extraction (CFOE) in very low birth weight (VLBW) infants during the first 48 h of life. Methods: We studied a prospective cohort of 60 VLBW infants admitted to our neonatal intensive care unit within the first 6 h of life between March 2010 and June 2012. rSO2 (expressed as a number of summary measures) was continuously monitored with near-infrared spectroscopy (INVOS 5100 Somanetic) during the first 48 h of life, SCVf was measured at 4-6, 12, 24 and 48 h after birth, and CFOE was calculated. Results: The mean gestational age was 27.9 (SD 2.39); 8 infants died (13.3%) and 7 developed IVH grade III-IV: 1 in the alive group and 6 in the deceased group (p <0.001). The odds ratio for death was 1.08 (95% CI: 1.015-1.15, p = 0.016) for each 10 periods of rSO2 values 2 ≤40% and SVCf

AB - Background: Brain vulnerability in the critically ill preterm newborn may be related to the burden of cerebral hypoxygenation and hypoperfusion during the immediate postnatal period. Objective: We determined the association between adverse outcomes [death or high grade intraventricular hemorrhage (IVH)] and continuous cerebral tissue oxygen saturation (rSO2), superior vena cava flow (SVCf) and cerebral fractional oxygen extraction (CFOE) in very low birth weight (VLBW) infants during the first 48 h of life. Methods: We studied a prospective cohort of 60 VLBW infants admitted to our neonatal intensive care unit within the first 6 h of life between March 2010 and June 2012. rSO2 (expressed as a number of summary measures) was continuously monitored with near-infrared spectroscopy (INVOS 5100 Somanetic) during the first 48 h of life, SCVf was measured at 4-6, 12, 24 and 48 h after birth, and CFOE was calculated. Results: The mean gestational age was 27.9 (SD 2.39); 8 infants died (13.3%) and 7 developed IVH grade III-IV: 1 in the alive group and 6 in the deceased group (p <0.001). The odds ratio for death was 1.08 (95% CI: 1.015-1.15, p = 0.016) for each 10 periods of rSO2 values 2 ≤40% and SVCf

KW - Cerebral fractional oxygen extraction

KW - Mortality

KW - Near-infrared spectroscopy

KW - Superior vena cava

KW - Very low birth weight infants

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