Cerebral parenchymal involvement in acute promyelocytic leukemia. A case report

E. M. Pogliani, C. Fowst, A. Marozzi, M. Salvatore, E. E. Polli

Research output: Contribution to journalArticlepeer-review


In February, 1982 a 45-year-old woman was admitted to the hospital for leukopenia and hemorrhagic diathesis. The bone marrow biopsy was positive for acute myeloid leukemia (AML). In a few days the patient developed leukocytosis (95% promyelocytic blasts) and disseminated intravascular coagulation (D.I.C.). She complained of severe headache and photophobia, and moderate nucal stiffness was present as the only neurological alteration. Examination of the CSF revealed blasts, and a cerebral computerized axial tomography (C.A.T.) showed a localization in the right temporal lobe. Complete marrow and central nervous system (CNS) remission were obtained by a single course of daunorubicin I.V. CNS remission was maintained even after a marrow relapse which occurred about two years later.

Original languageEnglish
Pages (from-to)71-73
Number of pages3
Issue number1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Hematology


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