Cerebral peduncle angle

An objective criterion for assessing progressive supranuclear palsy richardson syndrome

Girish M. Fatterpekar, August Dietrich, Patrizia Pantano, Luca Saba, Edmond A. Knopp, Maria Cristina Piattella, Eytan Raz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

OBJECTIVE. Several criteria for time-consuming volumetric measurements of progressive supranuclear palsy Richardson syndrome subtype (PSP-RS) have been proposed. These often require image reconstruction in different planes for proper assessment. The purpose of this study was to evaluate the cerebral peduncle angle as a simple and reproducible measure of midbrain atrophy in patients with PSP-RS. MATERIALS AND METHODS. The records of 15 patients with PSP-RS were retrospectively identified. The records of 31 age-matched healthy control subjects, 15 patients with multiple-system atrophy, and 22 patients with Parkinson disease were included for comparison. Two neuroradiologists individually assessed these studies for midbrain atrophy by evaluating the cerebral peduncle angle, that is, the angle between the two cerebral peduncles. RESULTS. The cerebral peduncle angle measurements were 62.1° (SD, 6.8°) in PSP-RS patients, 51.2° (SD, 10.1°) in healthy control subjects, 55.7° (SD, 11.6°) in patients with multiple- system atrophy, and 53.7° (SD, 8.5°) in patients with Parkinson disease. A statistically significant difference was found in the cerebral peduncle angle measurements (observer 1, p = 0.015; observer 2, p = 0.004) between the PSP-RS patients and the other subgroups. Bland- Altman analysis showed a bias of 0.6° (95% limits of agreement, 6.9°, -5.8°), and intraobserver variability analysis showed a bias of 0.5° (4.1°, -3°). CONCLUSION. The cerebral peduncle angle is a simple, easy-to-calculate, and reproducible measure of midbrain atrophy. It is a useful criterion for differentiating patients with PSPRS from healthy persons and from patients with multiple-system atrophy or Parkinson disease.

Original languageEnglish
Pages (from-to)386-391
Number of pages6
JournalAmerican Journal of Roentgenology
Volume205
Issue number2
DOIs
Publication statusPublished - Aug 1 2015

Fingerprint

Progressive Supranuclear Palsy
Multiple System Atrophy
Mesencephalon
Atrophy
Parkinson Disease
Healthy Volunteers
Cerebral Peduncle
Observer Variation
Computer-Assisted Image Processing

Keywords

  • Atrophy
  • Cerebral peduncle
  • Neurodegenerative disease
  • Progressive supranuclear palsy
  • Richardson syndrome

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Cerebral peduncle angle : An objective criterion for assessing progressive supranuclear palsy richardson syndrome. / Fatterpekar, Girish M.; Dietrich, August; Pantano, Patrizia; Saba, Luca; Knopp, Edmond A.; Piattella, Maria Cristina; Raz, Eytan.

In: American Journal of Roentgenology, Vol. 205, No. 2, 01.08.2015, p. 386-391.

Research output: Contribution to journalArticle

Fatterpekar, Girish M. ; Dietrich, August ; Pantano, Patrizia ; Saba, Luca ; Knopp, Edmond A. ; Piattella, Maria Cristina ; Raz, Eytan. / Cerebral peduncle angle : An objective criterion for assessing progressive supranuclear palsy richardson syndrome. In: American Journal of Roentgenology. 2015 ; Vol. 205, No. 2. pp. 386-391.
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abstract = "OBJECTIVE. Several criteria for time-consuming volumetric measurements of progressive supranuclear palsy Richardson syndrome subtype (PSP-RS) have been proposed. These often require image reconstruction in different planes for proper assessment. The purpose of this study was to evaluate the cerebral peduncle angle as a simple and reproducible measure of midbrain atrophy in patients with PSP-RS. MATERIALS AND METHODS. The records of 15 patients with PSP-RS were retrospectively identified. The records of 31 age-matched healthy control subjects, 15 patients with multiple-system atrophy, and 22 patients with Parkinson disease were included for comparison. Two neuroradiologists individually assessed these studies for midbrain atrophy by evaluating the cerebral peduncle angle, that is, the angle between the two cerebral peduncles. RESULTS. The cerebral peduncle angle measurements were 62.1° (SD, 6.8°) in PSP-RS patients, 51.2° (SD, 10.1°) in healthy control subjects, 55.7° (SD, 11.6°) in patients with multiple- system atrophy, and 53.7° (SD, 8.5°) in patients with Parkinson disease. A statistically significant difference was found in the cerebral peduncle angle measurements (observer 1, p = 0.015; observer 2, p = 0.004) between the PSP-RS patients and the other subgroups. Bland- Altman analysis showed a bias of 0.6° (95{\%} limits of agreement, 6.9°, -5.8°), and intraobserver variability analysis showed a bias of 0.5° (4.1°, -3°). CONCLUSION. The cerebral peduncle angle is a simple, easy-to-calculate, and reproducible measure of midbrain atrophy. It is a useful criterion for differentiating patients with PSPRS from healthy persons and from patients with multiple-system atrophy or Parkinson disease.",
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AU - Saba, Luca

AU - Knopp, Edmond A.

AU - Piattella, Maria Cristina

AU - Raz, Eytan

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AB - OBJECTIVE. Several criteria for time-consuming volumetric measurements of progressive supranuclear palsy Richardson syndrome subtype (PSP-RS) have been proposed. These often require image reconstruction in different planes for proper assessment. The purpose of this study was to evaluate the cerebral peduncle angle as a simple and reproducible measure of midbrain atrophy in patients with PSP-RS. MATERIALS AND METHODS. The records of 15 patients with PSP-RS were retrospectively identified. The records of 31 age-matched healthy control subjects, 15 patients with multiple-system atrophy, and 22 patients with Parkinson disease were included for comparison. Two neuroradiologists individually assessed these studies for midbrain atrophy by evaluating the cerebral peduncle angle, that is, the angle between the two cerebral peduncles. RESULTS. The cerebral peduncle angle measurements were 62.1° (SD, 6.8°) in PSP-RS patients, 51.2° (SD, 10.1°) in healthy control subjects, 55.7° (SD, 11.6°) in patients with multiple- system atrophy, and 53.7° (SD, 8.5°) in patients with Parkinson disease. A statistically significant difference was found in the cerebral peduncle angle measurements (observer 1, p = 0.015; observer 2, p = 0.004) between the PSP-RS patients and the other subgroups. Bland- Altman analysis showed a bias of 0.6° (95% limits of agreement, 6.9°, -5.8°), and intraobserver variability analysis showed a bias of 0.5° (4.1°, -3°). CONCLUSION. The cerebral peduncle angle is a simple, easy-to-calculate, and reproducible measure of midbrain atrophy. It is a useful criterion for differentiating patients with PSPRS from healthy persons and from patients with multiple-system atrophy or Parkinson disease.

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KW - Neurodegenerative disease

KW - Progressive supranuclear palsy

KW - Richardson syndrome

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