Pressione di perfusione cerebrale, autoregolazione e doppler transcranico: Studio modellistico

Translated title of the contribution: Cerebral perfusion pressure, autoregulation and transcranial doppler: A modelling study

M. Giulioni, M. Ursino, C. A. Lodi, M. Mondani, C. Belvederi

Research output: Contribution to journalArticlepeer-review


In the severe brain damage, the relationships between systemic arterial pressure (SAP), intracranial pressure (ICP), cerebral perfusion pressure (CPP), cerebral blood volume (CBV), cerebral blood flow (CBF) and autoregulation are strictly related and can lead to complex alterations of intracranial dynamics, making the interpretation of ultrasonographic parameters particularly unwieldy. Aim of this work is to analyze the possible impact of CPP changes (caused either by SAP or ICP changes) on the parameters extrapolated from the Transcranial Doppler. The analysis has been performed by using an original mathematical model of cerebral hemodynamics and cerebrospinal fluid dynamics. The results show that the effect of CPP changes on the Transcranial Doppler waveform are similar, independently on whether CPP has been reduced by reducing mean SAP or increasing ICP. In order to obtain information on cerebral autoregulation, the relationships between several ultrasonographic parameters must be considered simultaneously (including systolic velocity, diastolic velocity, mean velocity, peak-to peak velocity amplitude). In particular, peak- to- peak velocity amplitude provides information on the obtainment of a maximal vasodilatory status, related with autoregulation lower limit and on intracranial compliance. Accordingly, a significant increase in the pulsatility index is associated with a critical fall in CPP (CPP

Translated title of the contributionCerebral perfusion pressure, autoregulation and transcranial doppler: A modelling study
Original languageItalian
Pages (from-to)145-148
Number of pages4
JournalRivista di Neurobiologia
Issue number2
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Neuroscience(all)


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