Cerebral preamyloid deposits and congophilic angiopathy in aged dogs

Giorgio Giaccone, Laura Verga, Mario Finazzi, Bianca Pollo, Fabrizio Tagliavini, Blas Frangione, Orso Bugiani

Research output: Contribution to journalArticle

Abstract

The brains of 7 dogs aged 6 to 18 years have been histochemically and immunohistochemically investigated at the light- and electron microscopy levels for preamyloid deposits and amyloid fibrils to verify the hypothesis that the accumulation of cleavage products of amyloid precursor protein is related not only to Alzheimer's disease but also to the normal aging of the brain. Preamyloid deposits were detected in the neuropil of the cerebral cortex and neostriatum, whereas amyloid fibrils were found in the walls of parenchimal and leptomeningeal vessels. The densities of preamyloid deposits in the neuropil and of deposits of amyloid fibrils in the vessel walls were higher in the brains of the most aged dogs. These findings suggest that aging of the canine brain is characterized by an accumulation of intermediate cleavage products of the amyloid precursor protein in both the neuropil and the vessel walls, and by processing of these products to amyloid fibrils in the vessel walls.

Original languageEnglish
Pages (from-to)178-183
Number of pages6
JournalNeuroscience Letters
Volume114
Issue number2
DOIs
Publication statusPublished - Jul 3 1990

Keywords

  • Alzheimer's disease
  • Amyloid
  • Brain aging
  • Preamyloid deposit

ASJC Scopus subject areas

  • Neuroscience(all)

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