Cerebral venous thrombosis, intraventricular haemorrhage and white matter lesions in a preterm newborn with factor V (Leiden) mutation

L. A. Ramenghi, B. J. Gill, S. F. Tanner, D. Martinez, R. Arthur, M. I. Levene

Research output: Contribution to journalArticlepeer-review

Abstract

We report a preterm newborn who presented extensive cerebral vein thrombosis on MRI but no abnormal neurological signs. The baby underwent MRI as germinal-matrix intraventricular haemorrhage was revealed by a routine ultrasound brain scan performed on day 16; earlier ultrasound scans (day 2,7,12) were all normal. Cerebral vein thrombosis was diagnosed at the first MRI scan together with abnormal restriction in diffusion weighted imaging in the frontal white matter parenchyma. Bilateral micro-cavitations with a linear pattern of distribution reflecting the distribution of medullary veins developed a week later in the same white matter areas where abnormal diffusion weighted imaging was formerly noted. The baby was later found to be heterozygous for factor V Leiden.

Original languageEnglish
Pages (from-to)97-99
Number of pages3
JournalNeuropediatrics
Volume33
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • Cerebral Vein Thrombosis
  • Diffusion Weighted Imaging
  • Haemorrhagic Infarction
  • Medullary Veins
  • Thrombophilia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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