Cerebral visual impairment in periventricular leukomalacia

G. Lanzi, E. Fazzi, C. Uggetti, A. Cavallini, S. Danova, M. G. Egitto, O. Ferrari Ginevra, R. Salati, P. E. Bianchi

Research output: Contribution to journalArticle

Abstract

Infants with cerebral palsy (CP) frequently present cerebral visual impairment (CVI) often caused by damage to retrochiasmatic pathways. This is particularly true of subjects with damage to the periventricular white matter. Thirty-eight preterm infants with periventricular leukomalacia (PVL) diagnosed by MRI were examined to correlate binocular visual acuity with neuroradiological findings. Binocular visual acuity was evaluated using Teller Acuity Cards and a complete ophthalmological examination was also performed. Three infants with ROP III were excluded from the sample. The age of observation ranged from 20 months to 5 and a half years (mean 42 months). The possible involvement of the optic radiations and/or of the calcarine cortex was detected by brain MRI. Twenty-three infants (66%) presented visual impairment. Of these, 9 (26%) were totally or nearly totally blind and 14 (40%) were low vision children. The other 12 (34%) had normal (2) or near normal (9) vision. MRI findings correlated with visual acuity; a relationship was detected between the degree of visual acuity and the reduction of the peritrigonal white matter, and also between the degree of visual acuity and the extent of calcarine atrophy. This report clearly establishes a relationship between visual impairment and specific MRI findings in children with PVL. Teller Acuity Cards and MRI are useful for detecting potential visual impairment and for improving both the clinical diagnosis of these disorders and the therapeutic approach to these subjects.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalNeuropediatrics
Volume29
Issue number3
DOIs
Publication statusPublished - Jun 1998

Fingerprint

Periventricular Leukomalacia
Vision Disorders
Visual Acuity
Low Vision
Cerebral Palsy
Premature Infants
Atrophy
Observation
Radiation
Brain

Keywords

  • Cerebral palsy
  • Cerebral visual impairment
  • CP
  • CVI
  • Periventricular leukomalacia
  • PVL

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Cerebral visual impairment in periventricular leukomalacia. / Lanzi, G.; Fazzi, E.; Uggetti, C.; Cavallini, A.; Danova, S.; Egitto, M. G.; Ferrari Ginevra, O.; Salati, R.; Bianchi, P. E.

In: Neuropediatrics, Vol. 29, No. 3, 06.1998, p. 145-150.

Research output: Contribution to journalArticle

Lanzi, G, Fazzi, E, Uggetti, C, Cavallini, A, Danova, S, Egitto, MG, Ferrari Ginevra, O, Salati, R & Bianchi, PE 1998, 'Cerebral visual impairment in periventricular leukomalacia', Neuropediatrics, vol. 29, no. 3, pp. 145-150. https://doi.org/10.1055/s-2007-973551
Lanzi G, Fazzi E, Uggetti C, Cavallini A, Danova S, Egitto MG et al. Cerebral visual impairment in periventricular leukomalacia. Neuropediatrics. 1998 Jun;29(3):145-150. https://doi.org/10.1055/s-2007-973551
Lanzi, G. ; Fazzi, E. ; Uggetti, C. ; Cavallini, A. ; Danova, S. ; Egitto, M. G. ; Ferrari Ginevra, O. ; Salati, R. ; Bianchi, P. E. / Cerebral visual impairment in periventricular leukomalacia. In: Neuropediatrics. 1998 ; Vol. 29, No. 3. pp. 145-150.
@article{f7b8685787bc463ab843596b64c6ee9c,
title = "Cerebral visual impairment in periventricular leukomalacia",
abstract = "Infants with cerebral palsy (CP) frequently present cerebral visual impairment (CVI) often caused by damage to retrochiasmatic pathways. This is particularly true of subjects with damage to the periventricular white matter. Thirty-eight preterm infants with periventricular leukomalacia (PVL) diagnosed by MRI were examined to correlate binocular visual acuity with neuroradiological findings. Binocular visual acuity was evaluated using Teller Acuity Cards and a complete ophthalmological examination was also performed. Three infants with ROP III were excluded from the sample. The age of observation ranged from 20 months to 5 and a half years (mean 42 months). The possible involvement of the optic radiations and/or of the calcarine cortex was detected by brain MRI. Twenty-three infants (66{\%}) presented visual impairment. Of these, 9 (26{\%}) were totally or nearly totally blind and 14 (40{\%}) were low vision children. The other 12 (34{\%}) had normal (2) or near normal (9) vision. MRI findings correlated with visual acuity; a relationship was detected between the degree of visual acuity and the reduction of the peritrigonal white matter, and also between the degree of visual acuity and the extent of calcarine atrophy. This report clearly establishes a relationship between visual impairment and specific MRI findings in children with PVL. Teller Acuity Cards and MRI are useful for detecting potential visual impairment and for improving both the clinical diagnosis of these disorders and the therapeutic approach to these subjects.",
keywords = "Cerebral palsy, Cerebral visual impairment, CP, CVI, Periventricular leukomalacia, PVL",
author = "G. Lanzi and E. Fazzi and C. Uggetti and A. Cavallini and S. Danova and Egitto, {M. G.} and {Ferrari Ginevra}, O. and R. Salati and Bianchi, {P. E.}",
year = "1998",
month = "6",
doi = "10.1055/s-2007-973551",
language = "English",
volume = "29",
pages = "145--150",
journal = "Neuropediatrics",
issn = "0174-304X",
publisher = "Hippokrates Verlag GmbH",
number = "3",

}

TY - JOUR

T1 - Cerebral visual impairment in periventricular leukomalacia

AU - Lanzi, G.

AU - Fazzi, E.

AU - Uggetti, C.

AU - Cavallini, A.

AU - Danova, S.

AU - Egitto, M. G.

AU - Ferrari Ginevra, O.

AU - Salati, R.

AU - Bianchi, P. E.

PY - 1998/6

Y1 - 1998/6

N2 - Infants with cerebral palsy (CP) frequently present cerebral visual impairment (CVI) often caused by damage to retrochiasmatic pathways. This is particularly true of subjects with damage to the periventricular white matter. Thirty-eight preterm infants with periventricular leukomalacia (PVL) diagnosed by MRI were examined to correlate binocular visual acuity with neuroradiological findings. Binocular visual acuity was evaluated using Teller Acuity Cards and a complete ophthalmological examination was also performed. Three infants with ROP III were excluded from the sample. The age of observation ranged from 20 months to 5 and a half years (mean 42 months). The possible involvement of the optic radiations and/or of the calcarine cortex was detected by brain MRI. Twenty-three infants (66%) presented visual impairment. Of these, 9 (26%) were totally or nearly totally blind and 14 (40%) were low vision children. The other 12 (34%) had normal (2) or near normal (9) vision. MRI findings correlated with visual acuity; a relationship was detected between the degree of visual acuity and the reduction of the peritrigonal white matter, and also between the degree of visual acuity and the extent of calcarine atrophy. This report clearly establishes a relationship between visual impairment and specific MRI findings in children with PVL. Teller Acuity Cards and MRI are useful for detecting potential visual impairment and for improving both the clinical diagnosis of these disorders and the therapeutic approach to these subjects.

AB - Infants with cerebral palsy (CP) frequently present cerebral visual impairment (CVI) often caused by damage to retrochiasmatic pathways. This is particularly true of subjects with damage to the periventricular white matter. Thirty-eight preterm infants with periventricular leukomalacia (PVL) diagnosed by MRI were examined to correlate binocular visual acuity with neuroradiological findings. Binocular visual acuity was evaluated using Teller Acuity Cards and a complete ophthalmological examination was also performed. Three infants with ROP III were excluded from the sample. The age of observation ranged from 20 months to 5 and a half years (mean 42 months). The possible involvement of the optic radiations and/or of the calcarine cortex was detected by brain MRI. Twenty-three infants (66%) presented visual impairment. Of these, 9 (26%) were totally or nearly totally blind and 14 (40%) were low vision children. The other 12 (34%) had normal (2) or near normal (9) vision. MRI findings correlated with visual acuity; a relationship was detected between the degree of visual acuity and the reduction of the peritrigonal white matter, and also between the degree of visual acuity and the extent of calcarine atrophy. This report clearly establishes a relationship between visual impairment and specific MRI findings in children with PVL. Teller Acuity Cards and MRI are useful for detecting potential visual impairment and for improving both the clinical diagnosis of these disorders and the therapeutic approach to these subjects.

KW - Cerebral palsy

KW - Cerebral visual impairment

KW - CP

KW - CVI

KW - Periventricular leukomalacia

KW - PVL

UR - http://www.scopus.com/inward/record.url?scp=0031869371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031869371&partnerID=8YFLogxK

U2 - 10.1055/s-2007-973551

DO - 10.1055/s-2007-973551

M3 - Article

C2 - 9706625

AN - SCOPUS:0031869371

VL - 29

SP - 145

EP - 150

JO - Neuropediatrics

JF - Neuropediatrics

SN - 0174-304X

IS - 3

ER -