Cerebral Whipple's disease: Clinical and cerebrospinal fluid findings

F. Carella, P. Valla, G. Bernardi, F. Parente, A. Costa, S. Lodrini

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The case of a patient who had a relapse of cerebral Whipple 's disease (WD) one year after discontinuation of a two-years' antibiotic treatment is reported. Neither the clinical course nor the results of magnetic resonance imaging (MRI) and routine examination of the cerebrospinal fluid (CSF) allowed the caring physician to predict the relapse. Retrospective analysis of serial specimens of CSF showed that slight CSF leucocytosis and intrathecal synthesis of IgA might have suggested persistence of infection. The decision to stop antibiotic therapy in cerebral WD is difficult, but evaluation of cell counts and of intrathecal synthesis of IgA may help in the decision. Some patients may need to take treatment indefinitely.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalItalian Journal of Neurological Sciences
Issue number2
Publication statusPublished - 1998


  • Whipple's disease, cerebrospinal fluid, immunoglobulins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology


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