Cerebroplacental Doppler ratio and placental histopathological features in pregnancies complicated by fetal growth restriction

Arsenio Spinillo, Barbara Gardella, Silvia Bariselli, Alessandro Alfei, Enrico Maria Silini, Barbara Dal Bello

Research output: Contribution to journalArticle

Abstract

Objective: To correlate placental pathologic lesions, as defined by the Society for Pediatric Pathology, to the severity of the ratio of the pulsatility Doppler index (PI) of the fetal middle cerebral artery to that of the umbilical artery (cerebroplacental ratio, CPR). Study design: A cohort-study of 176 singleton pregnancies complicated by fetal growth restriction (FGR). Results: The mean values of gestational age, birth weight and CPR of the entire cohort were 33.9 ± 3.6 weeks, 1552 ± 561 g, and 1.33 ± 0.68, respectively. In ordered logistic regression analysis, after adjustment for potential confounders, muscularised arteries (Odds Ratio [OR] = 3.14; 95% confidence intervals [CI] = 1.58-6.28, P = 0.001), mural hypertrophy (OR = 2.35; 95% CI = 1.26-4.4, P = 0.008), immature intermediate trophoblast (OR = 2.0; 95% CI = 1.07-3.71, P = 0.03) and maternal vascular underperfusion (OR = 2.32; 95% CI = 1.25-4.23, P = 0.007) were the only parameters associated with severity of CPR. Conclusions: The correlation between placental histological findings indicating maternal underperfusion and placental occlusion suggest that forced centralization of fetal circulation in FGR could be at least partially attributable to the hemodynamic consequences of increased placental vascular resistance.

Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalJournal of Perinatal Medicine
Volume42
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Cerebroplacental Doppler ratio
  • Fetal brain sparing
  • Fetal growth restriction
  • Placenta histology preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

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