Cerebrospinal fluid Alzheimer's biomarker profiles in CNS infections

Jan Jessen Krut, Henrik Zetterberg, Kaj Blennow, Paola Cinque, Lars Hagberg, Richard W. Price, Marie Studahl, Magnus Gisslén

Research output: Contribution to journalArticle

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Abstract

The cerebrospinal fluid (CSF) biomarker profile in Alzheimer's disease (AD) is characterized by decreased beta amyloid (Aβ1-42), increased total and hyperphosphorylated tau (t-tau and p-tau, respectively), which is a useful diagnostic tool and gives insight in the pathogenesis of AD. It is of importance to study how these biomarkers react in other CNS diseases; therefore, we decided to analyse amyloid and tau biomarkers in different CNS infections. We also included analysis of soluble amyloid precursor proteins (sAPPα and -β). CSF Aβ1-42, sAPPα and -β, t-tau and p-tau were analysed in bacterial meningitis (n = 12), Lyme neuroborreliosis (n = 13), herpes simplex virus type 1 (HSV-1) encephalitis (n = 10), HIV-associated dementia (HAD) (n = 21), AD (n = 21) and healthy controls (n = 42). Concurrent with AD, Aβ1-42 was decreased in all groups except neuroborreliosis compared to controls. HSV-1 encephalitis, bacterial meningitis and HAD showed lower concentrations of sAPPα and -β compared to AD. T-tau was increased in AD and HSV-1 encephalitis compared to all other groups. P-tau was higher in AD and HSV-1 encephalitis compared to bacterial meningitis, HAD and control. Decreased CSF Aβ1-42, sAPPα and -β in various CNS infections imply an effect of neuroinflammation on amyloid metabolism which is similar in regard to AD concerning Aβ1-42, but differs concerning sAPPα and -β. These results clearly indicate different pathologic pathways in AD and infectious CNS disease and may provide help in the differential biomarker diagnostics. Increased p-tau in HSV-1 encephalitis probably reflect acute neuronal damage and necrosis.

Original languageEnglish
Pages (from-to)620-626
Number of pages7
JournalJournal of Neurology
Volume260
Issue number2
DOIs
Publication statusPublished - Feb 2013

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Cerebrospinal Fluid
Alzheimer Disease
Biomarkers
Human Herpesvirus 1
Encephalitis
Infection
AIDS Dementia Complex
Bacterial Meningitides
Amyloid
Central Nervous System Diseases
Lyme Neuroborreliosis
Amyloid beta-Protein Precursor
Communicable Diseases
Necrosis

Keywords

  • Amyloid
  • Bacterial infections
  • Central nervous system
  • Herpes encephalitis
  • HIV-associated dementia (MesH term AIDS dementia complex)
  • Tau protein

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Krut, J. J., Zetterberg, H., Blennow, K., Cinque, P., Hagberg, L., Price, R. W., ... Gisslén, M. (2013). Cerebrospinal fluid Alzheimer's biomarker profiles in CNS infections. Journal of Neurology, 260(2), 620-626. https://doi.org/10.1007/s00415-012-6688-y

Cerebrospinal fluid Alzheimer's biomarker profiles in CNS infections. / Krut, Jan Jessen; Zetterberg, Henrik; Blennow, Kaj; Cinque, Paola; Hagberg, Lars; Price, Richard W.; Studahl, Marie; Gisslén, Magnus.

In: Journal of Neurology, Vol. 260, No. 2, 02.2013, p. 620-626.

Research output: Contribution to journalArticle

Krut, JJ, Zetterberg, H, Blennow, K, Cinque, P, Hagberg, L, Price, RW, Studahl, M & Gisslén, M 2013, 'Cerebrospinal fluid Alzheimer's biomarker profiles in CNS infections', Journal of Neurology, vol. 260, no. 2, pp. 620-626. https://doi.org/10.1007/s00415-012-6688-y
Krut, Jan Jessen ; Zetterberg, Henrik ; Blennow, Kaj ; Cinque, Paola ; Hagberg, Lars ; Price, Richard W. ; Studahl, Marie ; Gisslén, Magnus. / Cerebrospinal fluid Alzheimer's biomarker profiles in CNS infections. In: Journal of Neurology. 2013 ; Vol. 260, No. 2. pp. 620-626.
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