Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis

Enrico Fainardi, Daria Bortolotti, Silvia Bolzani, Massimiliano Castellazzi, Carmine Tamborino, Gloria Roversi, Eleonora Baldi, Maria Luisa Caniatti, Ilaria Casetta, Valentina Gentili, Enrico Granieri, Roberta Rizzo, M. R. Tola, F. Dallocchio, T. Bellini, A. Rotola, D. Di Luca, S. Seraceni, C. Contini, S. SabbioniM. Negrini, M. Tognon, T. Antonelli, E. Groppo, M. Gentile, S. Ceruti, M. R. Manfrinato, A. Trentini, E. Miotto, M. Ferracin, E. Mazzoni, S. Pietrobon, I. Masini, J. C. Rotondo, F. Martini, A. Baruzzi, R. Roberto D'Alessandro, R. Michelucci, F. Salvi, S. Stecchi, C. Scandellari, G. Terzano, F. Granella, P. Nichelli, P. Sola, D. Ferraro, F. Vitetta, A. M. Simone, R. Bedin, N. Marcello, L. Motti, S. Montepietra, D. Guidetti, P. Immovilli, E. Montanari, I. Pesci, A. Guareschi, G. Greco, M. Santangelo, A. M. Mauro, S. Malagù, F. Rasi, M. Spadoni, M. Galeotti, L. Fiorani, W. Neri, A. Ravasio, M. Pasquinelli, S. Gutman, C. Monaldini

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The relevance of human leukocyte antigen (HLA)-G in dimeric form in multiple sclerosis (MS) is still unknown. Objective: To investigate the contribution of cerebrospinal fluid (CSF) HLA-G dimers in MS pathogenesis. Methods: CSF amounts of 78-kDa HLA-G dimers were measured by western blot analysis in 80 MS relapsing-remitting MS (RRMS) patients and in 81 inflammatory and 70 non-inflammatory controls. Results: CSF amounts of 78kDa HLA-G dimers were more frequent in RRMS than in inflammatory (p

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalMultiple Sclerosis Journal
Volume22
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • CSF levels
  • dimeric form
  • HLA-G
  • MRI activity
  • Multiple Sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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