TY - JOUR
T1 - Cerebrospinal fluid and serum neuron-specific enolase in acute benign headache
AU - Casmiro, M.
AU - Scarpa, E.
AU - Cortelli, P.
AU - Vignatelli, L.
PY - 2008/5
Y1 - 2008/5
N2 - We determined the cerebrospinal fluid (CSF) and serum neuron-specific enolase (NSE) concentrations in 19 patients with acute benign headache. All patients had normal neurological examination, CSF and head computed tomography scan. The final diagnoses were: primary thunderclap headache (n = 7), primary exertional headache (n = 3), primary cough headache (n = 1), migraine without aura (n = 4), headache unspecified (n = 2), probable infrequent episodic tension-type headache (n = 1), headache attributed to hypertensive crisis without hypertensive encephalopathy (n = 1). A group of 108 healthy subjects served as controls. CSF NSE concentration was 14.16 ng/ml [95% confidence interval (CI) 11.86, 16.47)] in the headache sample (controls 17.19 ng/ml, 95% CI 16.23, 18.15). Serum NSE concentration was 7.50 ng/ml (95% CI 5.20, 9.80) in the headache sample (controls 8.45 ng/ml, 95% CI 7.67, 9.23). CSF/serum ratio was 2.81 (95% CI 2.21, 3.40) in the headache sample (controls 2.23, 95% CI 2.03, 2.42). Acute benign headache is not associated with neuronal damage as estimated by means of CSF and serum NSE concentration.
AB - We determined the cerebrospinal fluid (CSF) and serum neuron-specific enolase (NSE) concentrations in 19 patients with acute benign headache. All patients had normal neurological examination, CSF and head computed tomography scan. The final diagnoses were: primary thunderclap headache (n = 7), primary exertional headache (n = 3), primary cough headache (n = 1), migraine without aura (n = 4), headache unspecified (n = 2), probable infrequent episodic tension-type headache (n = 1), headache attributed to hypertensive crisis without hypertensive encephalopathy (n = 1). A group of 108 healthy subjects served as controls. CSF NSE concentration was 14.16 ng/ml [95% confidence interval (CI) 11.86, 16.47)] in the headache sample (controls 17.19 ng/ml, 95% CI 16.23, 18.15). Serum NSE concentration was 7.50 ng/ml (95% CI 5.20, 9.80) in the headache sample (controls 8.45 ng/ml, 95% CI 7.67, 9.23). CSF/serum ratio was 2.81 (95% CI 2.21, 3.40) in the headache sample (controls 2.23, 95% CI 2.03, 2.42). Acute benign headache is not associated with neuronal damage as estimated by means of CSF and serum NSE concentration.
KW - Acute benign headache
KW - Biochemical markers
KW - Neuron-specific enolase
KW - Normal values
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U2 - 10.1111/j.1468-2982.2007.01508.x
DO - 10.1111/j.1468-2982.2007.01508.x
M3 - Article
C2 - 18294249
AN - SCOPUS:41849105803
VL - 28
SP - 506
EP - 509
JO - Cephalalgia
JF - Cephalalgia
SN - 0333-1024
IS - 5
ER -