Cerebrospinal fluid biomarkers profile of idiopathic normal pressure hydrocephalus

Tommaso Schirinzi, Giulia Maria Sancesario, Giulia Di Lazzaro, Alessio D'Elia, Paola Imbriani, Simona Scalise, Antonio Pisani

Research output: Contribution to journalReview article

Abstract

Idiopathic normal pressure hydrocephalus (iNPH) is a disabling neurological disorder whose potential treatability is significantly limited by diagnostic uncertainty. In fact, typical clinical presentation occurs at late phases of disease, when CSF shunting could be ineffective. In recent years, measurement of different CSF proteins, whose concentration directly reflects neuropathological changes of CNS, has significantly improved both diagnostic timing and accuracy of neurodegenerative disease. Unfortunately iNPH lacks neuropathological hallmarks allowing the identification of specific disease biomarkers. However, neuropathology of iNPH is so rich and heterogeneous that many processes can be tracked in CSF, including Alzheimer's disease core pathology, subcortical degeneration, neuroinflammation and vascular dysfunction. Indeed, a huge number of CSF biomarkers have been analyzed in iNPH patients, but a unifying profile has not been provided yet. In this brief survey, we thus attempted to summarize the main findings in the field of iNPH CSF biomarkers, aimed at outlining a synthetic model. Although defined cut-off values for biomarkers are not available, a better knowledge of CSF characteristics may definitely assist in diagnosing the disease.

Original languageEnglish
Pages (from-to)673-679
Number of pages7
JournalJournal of Neural Transmission
Volume125
Issue number4
DOIs
Publication statusPublished - Apr 2018

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