Cerebrospinal fluid circulation: Brain lymphatics, brain glymphatics, or both?

Carlo Bellini, Luca A. Ramenghi, Dario Paladini, Tommaso Bellini, Francesco Boccardo

Research output: Chapter in Book/Report/Conference proceedingChapter


We briefly review the role of lymphatic drainage of cerebrospinal fluid from the brain. In particular, we review the current hypotheses on the possible drainage of lymphatic fluid from the brain. The intriguing point is that although lymphatics are absent in the brain, a very complex brain-wide paravascular pathway for cerebrospinal fluid and interstitial fluid exchange is present which allows efficient clearance of solutes and waste from the brain. The role of cervical lymphatic vessels is critical and various models describing the anatomical connection between the subarachnoid space and the nasal lymphatic vessels are discussed.

Original languageEnglish
Title of host publicationThe Lymphatic System
Subtitle of host publicationComponents, Functions and Diseases
PublisherNova Science Publishers Inc
Number of pages14
ISBN (Electronic)9781634846905
ISBN (Print)9781634846899
Publication statusPublished - Jan 1 2016


  • Brain glymphatic system
  • Brain lymphatic system
  • Cervical lymphatic vessels

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)


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